Transfusions of CPDA-1 red blood cells stored for up to 28 days decrease donor exposures in very low-birth-weight premature infants

Transfusions of CPDA-1 red blood cells stored for up to 28 days decrease donor exposures in very low-birth-weight premature infants

Autor Cunha, DHF da Google Scholar
Dos Santos, Amelia Miyashiro Autor UNIFESP Google Scholar
Kopelman, B. I. Google Scholar
Areco, K. N. Google Scholar
Guinsburg, Ruth Autor UNIFESP Google Scholar
Peres, C. D. Google Scholar
Chiba, A. K. Google Scholar
Kuwano, S. T. Google Scholar
Terzian, CCN Google Scholar
Bordin, J. O. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The goal of this research was to study the safety and the efficacy of transfusing citrate-phosphate-adenine anticoagulant-preservative (CPDA-1) RBC stored for up to 28 days to reduce donor exposures in premature infants. A prospective randomized two-group study was conducted with very low-birth-weight premature infants that received at least one RBC transfusion during hospital stay. Neonates randomly assigned to Group 1 (26 infants) were transfused with CPDA-1 RBC stored for up to 28 days; those assigned to Group 2 (26 infants) received CPDA-1 RBC stored for up to 3 days. Demographic and transfusion-related data were collected. Neonates from both groups showed similar demographics and clinical characteristics. the number of transfusions per infant transfused was 4.4 +/- 4.0 in Group 1 and 4.2 +/- 3.1 in Group 2, and the number of donors per infant transfused was 1.5 +/- 0.8 (Group 1) and 4.3 +/- 3.4 (Group 2), P < 0.001. RBC transfusions containing 29.7 +/- 18.3 mmol L-1 of potassium (RBC stored for up to 28 days) did not cause clinical or biochemical changes and reduced donor exposures by 70.2%, compared to transfusions containing 19.8 +/- 12.3 mmol L-1 of potassium (RBC stored for up to 3 days), P < 0.001. in conclusion, RBC stored for up to 28 days safely reduced donor exposures in premature infants.
Palavra-chave blood donors
erythrocyte transfusion
hyperkalaemia
infant newborn
neonatal anaemia
premature infants
Idioma Inglês
Data de publicação 2005-12-01
Publicado em Transfusion Medicine. Oxford: Blackwell Publishing, v. 15, n. 6, p. 467-473, 2005.
ISSN 0958-7578 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing
Extensão 467-473
Fonte http://dx.doi.org/10.1111/j.1365-3148.2005.00624.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000233817400003
Endereço permanente http://repositorio.unifesp.br/handle/11600/28590

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