Does the less aggressive multimodal approach of treating bladder-prostate rhabdomyosarcoma preserve bladder function?

Does the less aggressive multimodal approach of treating bladder-prostate rhabdomyosarcoma preserve bladder function?

Autor Soler, R. Google Scholar
Macedo, A. Google Scholar
Bruschini, H. Google Scholar
Puty, F. Google Scholar
Caran, E. Google Scholar
Petrilli, A. Google Scholar
Garrone, G. Google Scholar
Srougi, M. Google Scholar
Ortiz, V Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Purpose: the treatment of bladder-prostate rhabdomyosarcoma has evolved into multimodal therapy, including chemotherapy, radiotherapy and organ sparing surgery with bladder preservation. We investigated bladder function in children who underwent multimodal therapy at our institution and retained the original bladder for at least 6 months after treatment ended.Materials and Methods: We evaluated 8 children with bladder-prostate rhabdomyosarcoma treated at our institution between 1999 and 2003 according to inclusion criteria. All patients underwent history, physical examination and urodynamic study at least 6 months after completion of treatment (range 6 to 39 months).Results: All patients were treated following the same chemotherapy and radiotherapy scheme. Three patients (37.5%) were asymptomatic and had normal urodynamic studies, and 1 had only dysuria (this patient later underwent continent urinary diversion with transverse colon). the 4 remaining patients had urological complaints, and the urodynamic findings were reduced bladder capacity in 4, overactivity plus sensory urgency in 2, sensory urgency only in 1 and suprapubic pain during filling in 1.Conclusions: Among 8 patients 3 had normal urinary function and 4 had minor tolerable alterations. Cystectomy and urinary diversion were later necessary in only 1 patient due to disabling dysuria. the fact that the original functioning bladder was preserved in 7 of 8 patients suggests the feasibility of multimodal therapy. Long-term followup will still be necessary for definite conclusions, since we recognize that the deleterious effects, mainly of radiotherapy, may take longer to become evident.
Palavra-chave bladder
prostate
rhabdomyosarcoma
radiotherapy
drug therapy
Idioma Inglês
Data de publicação 2005-12-01
Publicado em Journal of Urology. Philadelphia: Lippincott Williams & Wilkins, v. 174, n. 6, p. 2343-2346, 2005.
ISSN 0022-5347 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 2343-2346
Fonte http://dx.doi.org/10.1097/01.ju.0000180644.32615.39
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000233293700065
Endereço permanente http://repositorio.unifesp.br/handle/11600/28589

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