The Ala45Thr polymorphism of NEUROD1 is associated with type 1 diabetes in Brazilian women

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dc.contributor.author Oliveira, CSV
dc.contributor.author Hauache, O. M.
dc.contributor.author Vieira, JGH
dc.contributor.author Maciel, RMB
dc.contributor.author Sjoroos, M.
dc.contributor.author Canani, L. H.
dc.contributor.author Velho, G.
dc.contributor.author Gross, J. L.
dc.contributor.author Reis, A. F.
dc.date.accessioned 2016-01-24T12:38:12Z
dc.date.available 2016-01-24T12:38:12Z
dc.date.issued 2005-12-01
dc.identifier http://dx.doi.org/10.1016/S1262-3636(07)70237-9
dc.identifier.citation Diabetes & Metabolism. Moulineaux Cedex 9: Masson Editeur, v. 31, n. 6, p. 599-602, 2005.
dc.identifier.issn 1262-3636
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28585
dc.description.abstract Background: NEUROD1 encodes a transcription factor expressed in the endocrine pancreas, and involved in beta-cell development, function and mechanisms of apoptosis. in this study, we investigated the association of a frequent polymorphism in exon 2 of NEUROD1 (G > A; Ala45Thr) with Type 1 diabetes in Brazilian subjects.Methods: A population/association study comprising 246 unrelated Type 1 diabetic and 275 nondiabetic white Brazilian subjects. the Ala45Thr variant was genotyped by a PCR-RFLP method.Results: the frequency of the Thr allele was significantly higher in patients with Type 1 diabetes than in controls (42.3% vs 35.3%, P = 0.02). Stratification by gender showed that homozygosity for the Thr allele was associated with Type 1 diabetes in women with odds ratio of 3.66 (95 % C.I. 1.43-10.11, P = 0.009) as compared to homozygosity for the Ala allele. This effect was not observed in men.Conclusions: We found a gender-specific association of the Ala45Thr variant of NEUROD1 with Type 1 diabetes in Brazilian women. Our results suggest that gender as well as ethnicity might modulate the association of NEUROD1 with Type 1 diabetes. en
dc.format.extent 599-602
dc.language.iso eng
dc.publisher Masson Editeur
dc.relation.ispartof Diabetes & Metabolism
dc.rights Acesso restrito
dc.subject Type 1 diabetes mellitus en
dc.subject genetics en
dc.subject NEUROD1/BETA2 gene en
dc.subject association study en
dc.title The Ala45Thr polymorphism of NEUROD1 is associated with type 1 diabetes in Brazilian women en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Fleury Inst
dc.contributor.institution Wallac Oy
dc.contributor.institution Hosp Clin Porto Alegre
dc.contributor.institution Univ Fed Rio Grande Sul
dc.contributor.institution INSERM
dc.description.affiliation Universidade Federal de São Paulo, Mol Endocrinol Lab, São Paulo, Brazil
dc.description.affiliation Fleury Inst, São Paulo, Brazil
dc.description.affiliation Wallac Oy, PerkinElmer Life & Analyt Sci, FIN-20101 Turku, Finland
dc.description.affiliation Hosp Clin Porto Alegre, Div Endocrine, Porto Alegre, RS, Brazil
dc.description.affiliation Univ Fed Rio Grande Sul, Porto Alegre, RS, Brazil
dc.description.affiliation INSERM, U695, Paris, France
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Mol Endocrinol Lab, São Paulo, Brazil
dc.identifier.doi 10.1016/S1262-3636(07)70237-9
dc.description.source Web of Science
dc.identifier.wos WOS:000234215500013



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