Food restriction does not impair myocardial mechanics during the healing period of myocardial infarction in the rat

Food restriction does not impair myocardial mechanics during the healing period of myocardial infarction in the rat

Autor Peron, APDON Google Scholar
Saraiva, R. M. Google Scholar
Antonio, E. L. Google Scholar
Andriolo, A. Google Scholar
Tucci, PJF Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Papillary muscle mechanics were studied in 4 groups of rats: control (C) noninfarcted (n = 9), C infarcted (n = 9), food-restricted (FR) noninfarcted (n = 8) and FR infarcted (n = 9). Food-restricted animals were fed with 50% of chow consumed by the C rats. Myocardial infarction (MI) was promoted 6 weeks after food restriction, and myocardial contraction and relaxation were studied 3 weeks thereafter. Interestingly, MI size was larger (P <.04) in C (50% +/- 8%) than in FR (40% +/- 10%) rats. Maximal developed tension, rate of tension rise and decay, resting tension, and time to 50% relaxation studied at calcium concentrations of 0.5, 1.0, 1.5, 2.0, and 2.5 mmol/L were essentially similar in the 4 groups. Infarcted and noninfarcted FR rats presented longer time to peak tension. These unprecedented data indicated that food restriction (1) seems to engender myocardial protection against ischemia/reperfusion injury and (2) does not affect myocardial mechanical function at the end of the healing period of MI. (c) 2005 Elsevier Inc. All rights reserved.
Palavra-chave food restriction
myocardial infarction
rat
systolic function
diastolic function
papillary muscle
Idioma Inglês
Data de publicação 2005-12-01
Publicado em Nutrition Research. Oxford: Pergamon-Elsevier B.V., v. 25, n. 12, p. 1075-1084, 2005.
ISSN 0271-5317 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 1075-1084
Fonte http://dx.doi.org/10.1016/j.nutres.2005.10.003
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000234281200005
Endereço permanente http://repositorio.unifesp.br/handle/11600/28583

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta