Long-term effects of maternal diabetes on vascular reactivity and renal function in rat male offspring

Long-term effects of maternal diabetes on vascular reactivity and renal function in rat male offspring

Autor Rocha, Silvia de Oliveira Autor UNIFESP Google Scholar
Gomes, Guiomar Nascimento Autor UNIFESP Google Scholar
Forti, Andre Luis L Google Scholar
Franco, Maria do Carmo Pinho Autor UNIFESP Google Scholar
Fortes, Zuleica Bruno Google Scholar
Cavanal, Maria de Fátima Autor UNIFESP Google Scholar
Gil, Frida Zaladek Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Fetal growth impairment can occur in pregnancy complicated by diabetes. Although several studies have focused the effects of nutritional status on intrauterine development, the long-term impact of maternal diabetes on vascular and renal function in the offspring is poorly investigated. in the present study, blood pressure profiles and renal function parameters were investigated in the offspring of diabetic rats (DO). Female rats were made diabetic throughout gestation with a single dose of streptozotocyn (STZ) 10 d before mating. After weaning, the offspring had free access to food and water. Arterial pressure was evaluated every 15 d. Functional and morphometric kidney studies were performed in newborn, 3, 6 and 12-mo-old male rats in DO and in controls, C. Although maternal diabetes did not affect nephron number in the young adult rat, glomerular hypertrophy developed from 3 mo on. Glomerular Filtration Rate and Renal Plasma Flow were observed to be significantly decreased in DO when compared with C, from 3 mo on. in DO, hypertension was observed from 8 wk on and persisted elevated throughout the experimental period (12 mo). Vascular reactivity, evaluated in mesenteric arterial bed showed a decreased endothelium-dependent vasodilatation in 12-mo-old DO animals, while preserved response to sodium nitroprusside was demonstrated. Our data show that exposure to intrauterine diabetes induced by STZ does not affect nephron number in the young offspring but can cause permanent changes in Nitric Oxide (NO)-related vascular response, which, in turn may accelerate the natural age-related nephron loss.
Idioma Inglês
Data de publicação 2005-12-01
Publicado em Pediatric Research. Baltimore: Int Pediatric Research Foundation, Inc, v. 58, n. 6, p. 1274-1279, 2005.
ISSN 0031-3998 (Sherpa/Romeo, fator de impacto)
Publicador Int Pediatric Research Foundation, Inc
Extensão 1274-1279
Fonte http://dx.doi.org/10.1203/01.pdr.0000188698.58021.ff
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000233416500025
Endereço permanente http://repositorio.unifesp.br/handle/11600/28567

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