The percentage of positive biopsy cores as a predictor of disease recurrence in patients with prostate cancer treated with radical prostatectomy

The percentage of positive biopsy cores as a predictor of disease recurrence in patients with prostate cancer treated with radical prostatectomy

Autor Antunes, Alberto Azoubel Autor UNIFESP Google Scholar
Srougi, Miguel Autor UNIFESP Google Scholar
Dall'Oglio, Marcos Francisco Autor UNIFESP Google Scholar
Crippa, Alexandre Autor UNIFESP Google Scholar
Campagnari, João C. Google Scholar
Leite, Kátia Ramos Moreira Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Syrian Lebanese Hosp
Resumo OBJECTIVETo analyse the prognostic value of the percentage of positive biopsy cores (PPBC) in determining the pathological features and biochemical outcome of patients with prostate cancer treated by radical prostatectomy, as published data evaluating the prognostic value of PPBC in such patients have limitations.PATIENTS and METHODSA group of 534 patients with clinically localized prostate cancer was selected. the PPBC was defined as the number of positive biopsy cores/total number of biopsy cores x 100, and grouped into categories of <25%, 25.1-50%, 50.1-75% and 75.1-100%. Patients were divided in low-, intermediate- and high-risk groups according to the usual variables.RESULTSThe mean follow-up was 60.5 months. PPBC was associated with the preoperative serum prostate-specific antigen (PSA) level, biopsy Gleason score and clinical stage. On multivariate analysis, PPBC was a significant predictor of extraprostatic disease and seminal vesicle involvement. of patients in the four PPBC categories, 16%, 27%, 33% and 60%, respectively, had biochemical recurrence (P < 0.001), and on Cox regression analysis, PPBC was an independent predictor of disease recurrence. After segregating patients into risk groups the PPBC further stratified patients using thresholds of 75% (P = 0.006), 25% (P = 0.026) and 50% (P = 0.011) for low-, intermediate- and high-risk groups, respectively.CONCLUSIONSWe confirmed, with a longer follow-up, the clinical utility of the PPBC in determining the pathological features and biochemical outcome of patients with prostate cancer treated with radical prostatectomy, and established thresholds for use in patients in the three risk groups.
Palavra-chave prostate
cancer
biopsy
prostatectomy
prognostic factors
Idioma Inglês
Data de publicação 2005-12-01
Publicado em Bju International. Oxford: Blackwell Publishing, v. 96, n. 9, p. 1258-1263, 2005.
ISSN 1464-4096 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing
Extensão 1258-1263
Fonte http://dx.doi.org/10.1111/j.1464-410X.2005.05823.x
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000233205200015
Endereço permanente http://repositorio.unifesp.br/handle/11600/28561

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