Future perspectives in COPD

Future perspectives in COPD

Autor Celli, Bartolome Google Scholar
Goldstein, Roger Google Scholar
Jardim, José Roberto Autor UNIFESP Google Scholar
Knobil, Katharine Google Scholar
Instituição Tufts Univ
Univ Toronto
Universidade Federal de São Paulo (UNIFESP)
GlaxoSmithKline Inc
Resumo The pathophysiology of chronic obstructive pulmonary disease (COPD) is complex. the development of a multidimensional index-such as the BODE index-provides a means of classifying patients with COPD that also correlates with their prognosis. the individual components of the BODE index-body mass index (B), airflow obstruction (0) dyspnoea (D) and exercise capacity (E)-incorporate the pulmonary as well as the systemic effects seen in patients with COPD. Recent research has focussed on examining these impairments (including those of metabolism and inflammation) more carefully, and determining the effects of treatment on both the systemic and physiological aspects of COPD.Ongoing research initiatives by the public and private sector will contribute to our understanding of the disease processes underlying COPD, our understanding of the benefits associated with commonly used pharmacotherapies, as welt as laying the foundations for the development of new agents and therapeutic tools. Advances in the use of pharmacotherapy have been mirrored by research to better define the benefits associated with pulmonary rehabilitation. Many questions remain to be answered, but a comprehensive approach is now considered essential to the life-tong management of COPD, and will undoubtedly reduce the considerable socio-economic burden of COPD. (c) 2005 Elsevier B.V. All rights reserved.
Palavra-chave BODE
COPD
fluticasone propionate
international COPD
genetics network
oxidative stress
pulmonary rehabilitation
systemic inflammation
salmeterol
tiotropium
TORCH
UPLIFT
Idioma Inglês
Data de publicação 2005-12-01
Publicado em Respiratory Medicine. London: W B Saunders Co Ltd, v. 99, p. S41-S48, 2005.
ISSN 0954-6111 (Sherpa/Romeo, fator de impacto)
Publicador W B Saunders Co Ltd
Extensão S41-S48
Fonte http://dx.doi.org/10.1016/j.rmed.2005.09.014
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000234110100006
Endereço permanente http://repositorio.unifesp.br/handle/11600/28559

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