Interaction between M1-muscarinic and glutamatergic NMDA receptors on an inhibitory avoidance task

Interaction between M1-muscarinic and glutamatergic NMDA receptors on an inhibitory avoidance task

Autor Moreira, K. M. Google Scholar
Ferreira, T. L. Google Scholar
Fornari, R. V. Google Scholar
Figueredo, LZP Google Scholar
Oliveira, MGM Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo It has been demonstrated that MK-801 potentiates the effects of the non-selective muscarinic antagonist scopolamine on memory in rats. in this study, we investigated the role of the M1-muscarinic receptor in this interaction, by administering different doses of dicyclomine (DIC) and MK-801 in combination to male Wistar rats before training on the inhibitory avoidance task. MK-801 and DIC in sub-effective doses were administered in combination. It was observed that MK-801 at a dose of 0.1125 mg/kg with a sub-effective dose of 8 mg/kg of DIC significantly impaired the retention test when compared with saline-treated animals, i.e. MK-801 potentiated the effects of dicyclomine on memory impairment. Our results suggest an important role for the M1-muscarinic receptor in the synergistic interaction between cholinergic muscarinic and glutamatergic NMDA receptors, which is in line with the findings that the interactive modulation between these two neurotransmitters systems constitutes an important mechanism in cognitive functions. (c) 2005 Elsevier Inc. All rights reserved.
Palavra-chave learning
memory
dicyclomine
MK-801
passive avoidance
rat
impairment
Idioma Inglês
Data de publicação 2005-11-30
Publicado em Brain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 67, n. 6, p. 504-508, 2005.
ISSN 0361-9230 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 504-508
Fonte http://dx.doi.org/10.1016/j.brainresbull.2005.07.019
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000232959900009
Endereço permanente http://repositorio.unifesp.br/handle/11600/28558

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