Duplication of peri-kappa B and NF-kappa B sites of the first human immunodeficiency virus type 2 (HIV-2) transmission in Brazil

Duplication of peri-kappa B and NF-kappa B sites of the first human immunodeficiency virus type 2 (HIV-2) transmission in Brazil

Autor Fusuma, E. E. Google Scholar
Caruso, S. C. Google Scholar
Lopez, D. F. Google Scholar
Costa, L. J. Google Scholar
Janini, L. M. Google Scholar
De Mendonca, J. S. Google Scholar
Kallas, E. G. Google Scholar
Diaz, R. S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Hosp Servidor Publ Estadual
Resumo After the identification of HIV-2 in 1986, most of the cases reported have been concentrated in West Africa. We identified a case of HIV-2 infection in São Paulo, Brazil of a 45-year-old female who presented with Pneumocystis carinii pneumonia, with a CD4 count of 22 cells/ml. DNA samples from this patient were subjected to end-point PCR amplification of the LTR region. Clones were sequenced and subjected to phylogenetic analyses. All clones were subtype A related, and four presented an insertion, corresponding to an extra NF-kappa B site. This is the first confirmed case report of an HIV-2-infected subject identified in Brazil whose transmission occurred within the country. Furthermore, the NF-kappa B duplication would potentially be associated with an increase in viral cytopathogenicity. This raises concern for the need for permanent monitoring of the spread of HIV-2 in different areas of the world, even considering its lower rate of transmission and pathogenicity when compared to HIV-1.
Idioma Inglês
Data de publicação 2005-11-01
Publicado em Aids Research and Human Retroviruses. New Rochelle: Mary Ann Liebert Inc, v. 21, n. 11, p. 965-970, 2005.
ISSN 0889-2229 (Sherpa/Romeo, fator de impacto)
Publicador Mary Ann Liebert Inc
Extensão 965-970
Fonte http://dx.doi.org/10.1089/aid.2005.21.965
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000234099400011
Endereço permanente http://repositorio.unifesp.br/handle/11600/28537

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