Distribution of tccP in clinical enterohemorrhagic and enteropathogenic Escherichia coli isolates

Distribution of tccP in clinical enterohemorrhagic and enteropathogenic Escherichia coli isolates

Autor Garmendia, Junkal Google Scholar
Ren, Zhi Hong Google Scholar
Tennant, Sharon Google Scholar
Viera, Monica Aparecida Midolli Autor UNIFESP Google Scholar
Chong, Yu Wen Google Scholar
Whale, Andrew Google Scholar
Azzopardi, Kristy Google Scholar
Dahan, Sivan Google Scholar
Sircili, Marcelo Palma Google Scholar
Franzolin, Marcia Regina Google Scholar
Trabulsi, Luiz R. Google Scholar
Phillips, Alan Google Scholar
Gomes, Tania AT Autor UNIFESP Google Scholar
Xu, Jian Guo Google Scholar
Robins-Browne, Roy Google Scholar
Frankel, Gad Google Scholar
Instituição Univ London Imperial Coll Sci Technol & Med
CDC
Univ Melbourne
Universidade Federal de São Paulo (UNIFESP)
UCL Royal Free & Univ Coll Med Sch
Inst Butantan
Resumo Enterohemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC) are diarrheagenic pathogens that colonize the gut through the formation of attaching and effacing lesions, which depend on the translocation of effector proteins via a locus of enterocyte effacement-encoded type III secretion system. Recently, two effector proteins, EspJ and TccP, which are encoded by adjacent genes on prophage CP-933U in EHEC O157:H7, have been identified. TccP consists of a unique N-terminus region and several proline-rich domains. in this project we determined the distribution of tccP in O157:H7, in non-O157 EHEC, and in typical and atypical EPEC isolates. All the EHEC O157:H7 strains tested were tccP(+). Unexpectedly, tccP was also found in non-O157 EHEC, and in typical and atypical EPEC isolates, particularly in strains belonging to serogroups O26 (EHEC), O119 (typical EPEC), and O55 (atypical EPEC). We recorded some variation in the length of tccP, which reflects diversity in the number of the proline-rich repeats. These results show the existence of a class of attaching and effacing pathogens which express a combination of EPEC and EHEC virulence determinants.
Idioma Inglês
Data de publicação 2005-11-01
Publicado em Journal of Clinical Microbiology. Washington: Amer Soc Microbiology, v. 43, n. 11, p. 5715-5720, 2005.
ISSN 0095-1137 (Sherpa/Romeo, fator de impacto)
Publicador Amer Soc Microbiology
Extensão 5715-5720
Fonte http://dx.doi.org/10.1128/JCM.43.11.5715-5720.2005
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000233312200047
Endereço permanente http://repositorio.unifesp.br/handle/11600/28520

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