Sleep pattern in rats under different stress modalities

Sleep pattern in rats under different stress modalities

Autor Papale, L. A. Google Scholar
Andersen, M. L. Google Scholar
Antunes, I. B. Google Scholar
Alvarenga, TAF Google Scholar
Tufik, S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The present study was designed to evaluate the sleep pattern of rats submitted to chronic stressors (restraint, electrical footshock, swimming and cold) applied to male rats. After 48 h-baseline recording, rats were submitted to 4 days of chronic stress, and electrocorticogram recordings were carried out continuously. the stressors (footshock, swimming and cold) were applied twice a day for periods of 1 h at 9:00 and 16:00 h. Restrained animals were maintained in plastic cylinders for 22 h/day. the findings indicated that sleep efficiency, slow wave sleep (SWS) and paradoxical sleep (PS) were decreased on the third and fourth days of unpredictable shocks compared to baseline while immobilization and swimming presented reduced sleep efficiency in all 4-day recordings. swimming led to decreased SWS, whereas augmented PS was observed on the first day compared to baseline. Immobilization produced drastic alterations in sleep patterns since it reduced SWS during the 4 days and PS at days 1 to 4 in relation to baseline. of all stressors, cold was the only one that did not result in any statistical differences in sleep pattern during the light periods. Regarding the effect of stress compared to baseline on the dark recordings, PS was higher during cold stress periods, whereas footshock increased PS on days 2 to 4 and swimming only on day 2. Immobilization decreased PS throughout the 4 days of the stress sessions. Thus, the data suggest that different stress modalities result in distinct sleep responses, with immobilization producing the most dramatic alterations. (c) 2005 Elsevier B.V. All rights reserved.
Palavra-chave stress
sleep
immobilization
cold
swimming
footshock
Idioma Inglês
Data de publicação 2005-10-26
Publicado em Brain Research. Amsterdam: Elsevier B.V., v. 1060, n. 1-2, p. 47-54, 2005.
ISSN 0006-8993 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 47-54
Fonte http://dx.doi.org/10.1016/j.brainres.2005.08.021
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000233068100005
Endereço permanente http://repositorio.unifesp.br/handle/11600/28512

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