Interleukin-6 polymorphism and Helicobacter pylori infection in Brazilian adult patients with chronic gastritis

Interleukin-6 polymorphism and Helicobacter pylori infection in Brazilian adult patients with chronic gastritis

Author Gatti, L. L. Google Scholar
Tunes, M. Z. Google Scholar
Labio, R. W. de Google Scholar
Silva, L. C. Google Scholar
Smith, MDC Google Scholar
Payo, SLM Google Scholar
Institution Fac Med Marila
Universidade Federal de São Paulo (UNIFESP)
Univ Sagrado Coracao USC Bauru
Abstract Helicobacter pylori is recognised as the most common cause of chronic active gastritis and this bacterium is also an important pathogenic factor in peptic ulcer disease. the biological factors that influence clinical outcome in H. pylori infection have been extensively studied. in addition to immunological factors in the host, bacterial virulence determinants in H. pylori strains are likely to play a crucial role in gastric cancer development. Single-nucleotide polymorphisms at the 5' flanking region of the interleukin (IL)-6 gene promoter (G or C at -174 base) have been identified and individuals with the G allele at position -174 have been shown to produce higher levels of IL-6 than those with the C/C genotype. the mucosal levels of IL-6 were reported to be increased in H. pylori-associated gastritis. the present study was conducted to examine any relationship between inflammatory cytokine polymorphisms and the inflammatory process in mucosa infected by H. pylori. in our study we did not find any association between the C and G alleles in adult patients with chronic gastritis and inflammatory process in gastric mucosa.
Keywords Helicobacter pylori
interleukin-6 polymorphism
gastritis
Language English
Date 2005-10-01
Published in Clinical and Experimental Medicine. New York: Springer, v. 5, n. 3, p. 112-116, 2005.
ISSN 1591-8890 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 112-116
Origin http://dx.doi.org/10.1007/s10238-005-0074-3
Access rights Closed access
Type Article
Web of Science ID WOS:000233117500004
URI http://repositorio.unifesp.br/handle/11600/28488

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