Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging

Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging

Autor Rosa, Eloi F. Autor UNIFESP Google Scholar
Silva, Antonio C. Autor UNIFESP Google Scholar
Ihara, Silvia SM Autor UNIFESP Google Scholar
Mora, Oswaldo A. Autor UNIFESP Google Scholar
Aboulafia, Jeannine Autor UNIFESP Google Scholar
Nouailhetas, Viviane LA Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Aging and aerobic exercise are two conditions known to interfere with health and quality of life, most likely by inducing oxidative stress to the organism. We studied the effects of aging on the morphological and functional properties of skeletal, cardiac, and intestinal muscles and their corresponding oxidative status in C57BL/6 mice and investigated whether a lifelong moderate exercise program would exert a protective effect against some deleterious effects of aging. As expected, aged animals presented a significant reduction of physical performance, accompanied by a decrease of gastrocnemius cross-sectional area and cardiac hypertrophy. However, most interesting was that aging dramatically interfered with the intestinal structure, causing a significant thickening of the ileum muscular layer. Senescent intestinal myocytes displayed many mitochondria with disorganized cristae and the presence of cytosolic lamellar corpuscles. Lipid peroxidation of ileum and gastrocnemius muscle, but not of the heart, increased in aged mice, thus suggesting enhanced oxidative stress. With exception of the intestinal muscle responsiveness, animals submitted to a daily session of 60 min, 5 days/wk, at 13 up to 21 m/min of moderate running in treadmill during animal life span exhibited a reversion of all the observed aging effects on intestinal, skeletal, and heart muscles. the introduction of this lifelong exercise protocol prevented the enhancement of lipid peroxidation and sarcopenia and also preserved cellular and ultracellular structures of the ileum This is the first time that the protective effect of a lifelong regular aerobic physical activity against the deleterious effects of aging on intestinal muscle was demonstrated.
Palavra-chave moderate exercise
C57B/6 mice
ileum
oxidative stress
isometric contractile response
Idioma Inglês
Data de publicação 2005-10-01
Publicado em Journal of Applied Physiology. Bethesda: Amer Physiological Soc, v. 99, n. 4, p. 1569-1575, 2005.
ISSN 8750-7587 (Sherpa/Romeo, fator de impacto)
Publicador Amer Physiological Soc
Extensão 1569-1575
Fonte http://dx.doi.org/10.1152/japplphysiol.00417.2005
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000232276800046
Endereço permanente http://repositorio.unifesp.br/handle/11600/28481

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