Effects of long-term continuous exposure to light on memory and anxiety in mice

Effects of long-term continuous exposure to light on memory and anxiety in mice

Autor Castro, JPMV Google Scholar
Frussa, R. Google Scholar
Fukushiro, D. F. Google Scholar
Chinen, C. C. Google Scholar
Abilio, V Google Scholar
Silva, R. H. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The studies on the relationship between the light/dark cycle and memory function mostly used protocols of acute disruption of the circadian rhythm. the aim of the present study is to verify the effects of long-term continuous exposure to light on memory, anxiety and motor parameters of mice tested in the plus-maze discriminative avoidance task. Mice were conditioned to choose between the two enclosed arms (one aversive and one non-aversive) while avoiding the open arms of a modified elevated plus-maze apparatus. Memory was evaluated by the time spent in the aversive enclosed arm, anxiety was evaluated by the time spent in the open arms and locomotor behavior was evaluated by number of entries in the arms of the maze. the results showed that long-term (35-42 days) continuous light exposure did not modify memory or anxiety parameters but increased locomotor activity. While the increase in locomotor behavior is in line with previous studies, the unexpected absence of alterations in memory and anxiety (reported to be influenced by the circadian rhythm) is discussed. (c) 2005 Elsevier Inc. All rights reserved.
Palavra-chave memory
anxiety
locomotor activity
circadian rhythms
mice
Idioma Inglês
Data de publicação 2005-09-15
Publicado em Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 86, n. 1-2, p. 218-223, 2005.
ISSN 0031-9384 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 218-223
Fonte http://dx.doi.org/10.1016/j.physbeh.2005.07.009
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000232382000030
Endereço permanente http://repositorio.unifesp.br/handle/11600/28469

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