Immunological evaluation of allergic respiratory children with recurrent sinusitis

Immunological evaluation of allergic respiratory children with recurrent sinusitis

Autor Carvalho, Beatriz T Costa Google Scholar
Nagao, Aparecida Tiemi Google Scholar
Arslanian, Christina Google Scholar
Carneiro-Sampaio, Magda Maria Sales Google Scholar
Naspitz, Charles Kirov Autor UNIFESP Google Scholar
Sorensen, Ricardo Uhr Google Scholar
Leiva, Lily Google Scholar
Solé, Dirceu Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Fed Univ Ceara
Universidade de São Paulo (USP)
Louisiana State Univ
Resumo The objective of this study was to evaluate humoral immunity of allergic respiratory children with chronic/recurrent sinusitis. Twenty-seven allergic respiratory (persistent mild/moderate asthma and persistent allergic rhinitis) children (7-15-year old) with chronic or recurrent sinusitis were evaluated. Patients had symptoms and abnormal computer tomography scan even after two adequate treatments (long-lasting antibiotics, decongestants, and short-term oral corticosteroids). clinical examination, sweat test, total blood cell count, measurement of serum levels of: total and specific IgE, immunoglobulins (G, M, A), IgG subclasses, antibodies to Haemophilus influenza type b (IgG anti-Ps Hib) and pneumococcal serotypes (IgG anti-Ps 1, 3, 5, 6B, 9V, and 14) before and after active immunization (Act-Hib (R) and Pneumo23 (R), Aventis Pasteur SA, Lyon, France), Rubella neutralizing antibody titers and human immunodeficiency virus antibodies. Specific IgE to inhalant allergens higher than class III were observed in 24/27 patients. One patient had IgA plus IgG2 deficiency and other an IgG3 deficiency. Eight and 12 of 27 patients had IgG2 and IgG3 serum levels below 2.5th percentile, respectively. Immunological responses to protein and polysaccharide antigens were normal in all patients. Although our patients have been appropriately treated of their allergic diseases, they persisted with chronic/recurrent sinusitis and 60% of them had a documented osteomeatal complex blockade. in spite of the diagnosis of IgA plus IgG2 deficiency and an isolated IgG3 deficiency, in all patients an adequate response to Ps antigens was observed. Primary and/or secondary humoral immunodeficiency seems not to be the main cause of chronic/recurrent sinusitis in patients with respiratory allergic disease.
Palavra-chave chronic sinusitis
recurrent sinusitis
allergic rhinitis
immunoglobulin
IgG (immunoglobulin G) subclasses
pneumococcal antibodies
Idioma Inglês
Data de publicação 2005-09-01
Publicado em Pediatric Allergy and Immunology. Oxford: Blackwell Publishing, v. 16, n. 6, p. 534-538, 2005.
ISSN 0905-6157 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing
Extensão 534-538
Fonte http://dx.doi.org/10.1111/j.1399-3038.2005.00303.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000232006200012
Endereço permanente http://repositorio.unifesp.br/handle/11600/28464

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