Association study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependence

Association study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependence

Autor Messas, G. Google Scholar
Meira-Lima, I Google Scholar
Turchi, M. Google Scholar
Franco, O. Google Scholar
Guindalini, C. Google Scholar
Castelo, A. Google Scholar
Laranjeira, R. Google Scholar
Vallada, H. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Genetic factors play a role in the vulnerability to cocaine dependence. the reinforcing properties of cocaine are related to the dopaminergic system, and, in particular, the dopamine receptors have been linked to the reward mechanisms. the present study examines the role of the variants Taql A of the dopamine D2 receptor gene and Ball of the dopamine D3 receptor gene in a Brazilian sample consisting of 730 cocaine dependents and 782 healthy controls. the studied polymorphisms did not show any difference in allelic frequencies or genotypic distribution between the groups. Our data do not support a role for the dopamine D2 receptor gene Taql A and dopamine D3 receptor gene Ball gene polymorphisms in the susceptibility to cocaine dependence in a Brazilian sample.
Palavra-chave genetics
dopamine receptor
addiction
gene polymorphism
Idioma Inglês
Data de publicação 2005-09-01
Publicado em Psychiatric Genetics. Philadelphia: Lippincott Williams & Wilkins, v. 15, n. 3, p. 171-174, 2005.
ISSN 0955-8829 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 171-174
Fonte http://dx.doi.org/10.1097/00041444-200509000-00006
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000231808400005
Endereço permanente http://repositorio.unifesp.br/handle/11600/28462

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