Association study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependence

Association study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependence

Author Messas, G. Google Scholar
Meira-Lima, I Google Scholar
Turchi, M. Google Scholar
Franco, O. Google Scholar
Guindalini, C. Google Scholar
Castelo, A. Google Scholar
Laranjeira, R. Google Scholar
Vallada, H. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Genetic factors play a role in the vulnerability to cocaine dependence. the reinforcing properties of cocaine are related to the dopaminergic system, and, in particular, the dopamine receptors have been linked to the reward mechanisms. the present study examines the role of the variants Taql A of the dopamine D2 receptor gene and Ball of the dopamine D3 receptor gene in a Brazilian sample consisting of 730 cocaine dependents and 782 healthy controls. the studied polymorphisms did not show any difference in allelic frequencies or genotypic distribution between the groups. Our data do not support a role for the dopamine D2 receptor gene Taql A and dopamine D3 receptor gene Ball gene polymorphisms in the susceptibility to cocaine dependence in a Brazilian sample.
Keywords genetics
dopamine receptor
addiction
gene polymorphism
Language English
Date 2005-09-01
Published in Psychiatric Genetics. Philadelphia: Lippincott Williams & Wilkins, v. 15, n. 3, p. 171-174, 2005.
ISSN 0955-8829 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 171-174
Origin http://dx.doi.org/10.1097/00041444-200509000-00006
Access rights Closed access
Type Article
Web of Science ID WOS:000231808400005
URI http://repositorio.unifesp.br/handle/11600/28462

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