Analysis of bacteremia occurring in the presence of obstruction of the left colon in rats submitted to transoperative antegrade mechanical lavage

Analysis of bacteremia occurring in the presence of obstruction of the left colon in rats submitted to transoperative antegrade mechanical lavage

Autor Nunes, Benicio Luiz Bulhoes Barros Paula Google Scholar
Saad, Sarhan Sydney Autor UNIFESP Google Scholar
Juca, Mario Jorge Google Scholar
Porfirio, Zenaldo Google Scholar
Matos, Delcio Autor UNIFESP Google Scholar
Instituição Governor Lamenha Filho Univ Fdn Alagoas Hlth Sci
Universidade Federal de São Paulo (UNIFESP)
Fed Univ Alagoas
Resumo With the objective of determining the association between bacteremia and transoperative antegrade mechanical lavage of the colon in an experimental model of obstruction of the left colon in rats, 40 male Wistar rats aged between 90 and 120 days were divided randomly into four groups: A, with intestinal obstruction and with mechanical lavage of the colon; B, with intestinal obstruction and without mechanical lavage of the colon; C, without intestinal obstruction and with mechanical lavage of the colon; and D, without intestinal obstruction and without mechanical lavage of the colon. Analysis of the results showed that there was no bacteremia in the animals in the sham group. On the other hand, bacterial growth in blood cultures was found in three animals (30%) in group C and in four animals (40%) in group B. Positive blood culturing was presented by eight animals (80%) of the rats in group A, and variance analysis on this finding was statistically significant (p = .0029). It can be concluded that, in this experimental model, intestinal obstruction causes a fourfold increase in the risk of bacteremia, while lavage causes an almost threefold increase in the chance of bacterial dissemination into the blood stream. This explains why there was greater incidence of bacteremia in the animals with obstruction and with lavage.
Palavra-chave bacterial translocation
colon
intestinal obstruction
Irrigation
Idioma Inglês
Data de publicação 2005-09-01
Publicado em Journal of Investigative Surgery. Philadelphia: Taylor & Francis Inc, v. 18, n. 5, p. 233-240, 2005.
ISSN 0894-1939 (Sherpa/Romeo, fator de impacto)
Publicador Taylor & Francis Inc
Extensão 233-240
Fonte http://dx.doi.org/10.1080/08941930500248623
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000233300500004
Endereço permanente http://repositorio.unifesp.br/handle/11600/28455

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