Ocular toxoplasmosis in mice: comparison of two routes of infection

Ocular toxoplasmosis in mice: comparison of two routes of infection

Autor Tedesco, R. C. Google Scholar
Smith, R. L. Google Scholar
Corte-Real, S. Google Scholar
Calabrese, K. S. Google Scholar
Instituição Inst Oswaldo Cruz
Fdn Oswaldo Cruz Avenida Brasil
Universidade Federal de São Paulo (UNIFESP)
Resumo This paper aims to test the influence of route of infection (intravitreal and instillation) on the course of ocular toxoplasmosis in mice, using the Toxoplosma gondii Me-49 strain. All mice inoculated intravitreally or by instillation presented the same pattern of infection. Using either route, parasites were observed in the retinal vessel with the formation of a glial reaction in the inner plexiforme layer and discontinuity of the pigmented epithelium of the retina 7 days after infection. However, when the intravitreal route was used a more intense inflammatory infiltrate was observed in the retina. the results suggest that inoculation route remarkably influences the inflammatory pattern in ocular toxoplasmosis and that the instillation route should be preferentially used in experimental infections in the murine ocular model of infection by T. gondii, specially with small animals where there is extensive needle damage, which is not observed in the instillation route.
Palavra-chave Toxoplasma gondii
ocular toxoplasmosis
intravitreal
instillation
mouse model
Idioma Inglês
Data de publicação 2005-09-01
Publicado em Parasitology. New York: Cambridge Univ Press, v. 131, p. 303-307, 2005.
ISSN 0031-1820 (Sherpa/Romeo, fator de impacto)
Publicador Cambridge Univ Press
Extensão 303-307
Fonte http://dx.doi.org/10.1017/S003118200500781X
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000232315600003
Endereço permanente http://repositorio.unifesp.br/handle/11600/28454

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