Vitamin D endocrine system and the genetic susceptibility to diabetes, obesity and vascular disease. A review of evidence

Vitamin D endocrine system and the genetic susceptibility to diabetes, obesity and vascular disease. A review of evidence

Autor Reis, A. F. Google Scholar
Hauache, O. M. Google Scholar
Velho, G. Google Scholar
Instituição INSERM
Fleury Inst
Universidade Federal de São Paulo (UNIFESP)
Resumo The Vitamin D endocrine system regulates multiple aspects of calcium metabolism and cellular differentiation and replication in the immune system, endocrine pancreas, liver, skeletal muscles and adipocytes. It plays an important role in glucose homeostasis, notably, in the mechanism of insulin release. Actions of vitamin D are mediated by the binding of 1,25-(OH)2D3 to a specific cytosolic/nuclear vitamin D receptor (VDR), a member of the steroid/thyroid hormone receptor superfamily. Several frequent polymorphisms are found in the VDR gene and were reported to be associated with a variety of physiological and pathological phenotypes in many populations. in this paper, we will review the evidences suggesting associations of allelic variations in the VDR gene and phenotypes related to body weight, glucose homeostasis, diabetes and its vascular complications.
Palavra-chave vitamin D
vitamin D receptor (VDR)
vitamin D binding protein (DBP)
type 1 diabetes
type 2 diabetes
obesity
insulin secretion
insulin sensitivity
cardiovascular disease
Idioma Inglês
Data de publicação 2005-09-01
Publicado em Diabetes & Metabolism. Moulineaux Cedex 9: Masson Editeur, v. 31, n. 4, p. 318-325, 2005.
ISSN 1262-3636 (Sherpa/Romeo, fator de impacto)
Publicador Masson Editeur
Extensão 318-325
Fonte http://dx.doi.org/10.1016/S1262-3636(07)70200-8
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000232234100001
Endereço permanente http://repositorio.unifesp.br/handle/11600/28453

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