The importance of housing conditions on behavioral sensitization and tolerance to ethanol

The importance of housing conditions on behavioral sensitization and tolerance to ethanol

Autor Araujo, N. P. Google Scholar
Camarini, R. Google Scholar
Souza-Formigoni, MLO Google Scholar
Carvalho, R. C. Google Scholar
Abilio, V. C. Google Scholar
Silva, R. H. Google Scholar
Ricardo, V. P. Google Scholar
Ribeiro, R. D. Google Scholar
Frussa-Filho, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The differential outcomes of social isolation and crowding environment on the effects of single or repeated administration of ethanol on open-field behavior were examined in female mice. Whereas housing conditions did not alter the increase in locomotor activity induced by ethanol single administration, behavioral sensitization (a progressive increase of a drug effect following repeated drug administration) to the locomotor activating effect of ethanol was significantly greater in crowded mice as compared to isolated and control groups. Single administration of ethanol significantly decreased rearing frequency and increased immobility duration, there being tolerance to these ethanol behavior effects after repeated treatment. Social isolation attenuated the increase in immobility behavior induced by single administration of ethanol and potentiated the tolerance of ethanol-induced rearing decrease, verified after repeated treatment. These results point out that both sensitization and tolerance to the behavioral effects of ethanol can be critically influenced by housing conditions. (c) 2005 Elsevier Inc. All rights reserved.
Assunto ethanol
behavioral sensitization
social isolation
Idioma Inglês
Data 2005-09-01
Publicado em Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 82, n. 1, p. 40-45, 2005.
ISSN 0091-3057 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 40-45
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000232812600006

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