Sedative and anticonvulsant effects of hydroalcoholic extract of Equisetum arvense

Sedative and anticonvulsant effects of hydroalcoholic extract of Equisetum arvense

Autor Dos Santos, J. G. Google Scholar
Blanco, M. M. Google Scholar
Do Monte, FHM Google Scholar
Russi, M. Google Scholar
Lanziotti, VMNB Google Scholar
Leal, LKAM Google Scholar
Cunha, G. M. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
State Univ Santa Catarina
Fed Univ Ceara
Resumo The hydroalcoholic extract of Equisetum arvense (HAE) tested at the doses of 200 and 400 mg/kg showed a significant activity on the open-field, enhanced the number of falls in the rotarod reducing the time of permanence in the bar and increased the sleeping time (46% and 74%) in the barbiturate-induced sleeping time. in the pentylenetetrazole-seizure, it increased the first convulsion latency, diminished the severity of convulsions, reduced the percentage of animals which developed convulsion (50% and 25%) and protected animals from death. On the contrary, in the elevated plus maze, the doses 50, 100 and 150 mg/kg did not affect the evaluated parameters. Thus, HAE presented anticonvulsant and sedative effects. Phytochemical analysis detected the presence of tannins, saponins, sterols and flavonoids. (c) 2005 Elsevier B.V All rights reserved.
Palavra-chave hydroalcoholic extract
Equisetum arvense
CNS
Idioma Inglês
Data de publicação 2005-09-01
Publicado em Fitoterapia. Amsterdam: Elsevier B.V., v. 76, n. 6, p. 508-513, 2005.
ISSN 0367-326X (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 508-513
Fonte http://dx.doi.org/10.1016/j.fitote.2005.04.017
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000231985100002
Endereço permanente http://repositorio.unifesp.br/handle/11600/28447

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