Clinical features and outcomes of patients with diffuse unilateral subacute neuroretinitis treated with oral albendazole

Clinical features and outcomes of patients with diffuse unilateral subacute neuroretinitis treated with oral albendazole

Author Souza, E. C. Google Scholar
Casella, AMB Google Scholar
Nakashima, Y. Google Scholar
Monteiro, MLR Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fed Univ Londrina
Universidade de São Paulo (USP)
Abstract PURPOSE: To investigate the clinical features, visual function outcomes, and adverse events in patients with diffuse unilateral subacute neuroretinitis (DUSN) treated with high dose oral albendazole.DESIGN: Interventional case series.METHODS- Twelve Brazilian patients, aged 7 through 36 years, with active DUSN in the early or late clinical stage, were recruited for this study between 1999 and 2001. A small variant motile worm was found in 4 (33.3%) of these cases. All patients were treated exclusively with high-dose oral albendazole (400 mg/d) for 30 days.RESULTS: Improvement of visual acuity, visual field, and active ocular inflammatory signs was observed in all patients after 4 weeks of treatment (median follow-up: 3 years). Also, during the first weeks of treatment, evidence of worm inactivation was documented for the four patients with visible worms. No adverse drug side effects were observed in any of our cases during follow-up.CONCLUSION: High-dose oral albendazole seems to be safe and beneficial for patients with DUSN.
Language English
Date 2005-09-01
Published in American Journal of Ophthalmology. New York: Elsevier B.V., v. 140, n. 3, p. 437-445, 2005.
ISSN 0002-9394 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 437-445
Origin http://dx.doi.org/10.1016/j.ajo.2005.03.065
Access rights Closed access
Type Article
Web of Science ID WOS:000231929300011
URI http://repositorio.unifesp.br/handle/11600/28444

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