Clinical features and outcomes of patients with diffuse unilateral subacute neuroretinitis treated with oral albendazole

Clinical features and outcomes of patients with diffuse unilateral subacute neuroretinitis treated with oral albendazole

Autor Souza, E. C. Google Scholar
Casella, AMB Google Scholar
Nakashima, Y. Google Scholar
Monteiro, MLR Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Fed Univ Londrina
Universidade de São Paulo (USP)
Resumo PURPOSE: To investigate the clinical features, visual function outcomes, and adverse events in patients with diffuse unilateral subacute neuroretinitis (DUSN) treated with high dose oral albendazole.DESIGN: Interventional case series.METHODS- Twelve Brazilian patients, aged 7 through 36 years, with active DUSN in the early or late clinical stage, were recruited for this study between 1999 and 2001. A small variant motile worm was found in 4 (33.3%) of these cases. All patients were treated exclusively with high-dose oral albendazole (400 mg/d) for 30 days.RESULTS: Improvement of visual acuity, visual field, and active ocular inflammatory signs was observed in all patients after 4 weeks of treatment (median follow-up: 3 years). Also, during the first weeks of treatment, evidence of worm inactivation was documented for the four patients with visible worms. No adverse drug side effects were observed in any of our cases during follow-up.CONCLUSION: High-dose oral albendazole seems to be safe and beneficial for patients with DUSN.
Idioma Inglês
Data de publicação 2005-09-01
Publicado em American Journal of Ophthalmology. New York: Elsevier B.V., v. 140, n. 3, p. 437-445, 2005.
ISSN 0002-9394 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 437-445
Fonte http://dx.doi.org/10.1016/j.ajo.2005.03.065
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000231929300011
Endereço permanente http://repositorio.unifesp.br/handle/11600/28444

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