Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats

Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats

Autor Hoexter, Marcelo Queiroz Autor UNIFESP Google Scholar
Rosa, Pedro S. Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Luiz Eugenio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Purpose: To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy. We hypothesized that prolonged caffeine consumption or its withdrawal would alter adenosine levels and hence alter seizure susceptibility.Methods: We administered a 0.1% caffeine solution in the drinking water of adult male Wistar rats over a 2-week period. We challenged another group of animals with the same doses of pilocarpine or kainate 12 h after the withdrawal of the same caffeine-administration protocol.Results: This did not alter the threshold for the induction of seizures by a subconvulsant dose of pilocarpine (200 mg/kg, i.p.) or kainic acid (8 mg/kg, i.p.). Similarly, challenging another group of animals with the same doses of pilocarpine or kainate 12 h after the withdrawal of the same caffeine-administration protocol did not lead to any significant changes in seizures.Conclusions: With the pilocarpine model of epilepsy, we were not able to find any significant difference in seizure profile that could stem from either caffeine administration or its withdrawal. Despite the extensive laboratory evidence on the convulsant properties of xanthine derivatives in animal models of epilepsy, such strong evidence is lacking in clinical settings. Our current findings with the administration of caffeine at doses similar to those of daily life both support and confirm the clinical experience.
Palavra-chave status epilepticus
xanthines
adenosine
anticonvulsant
spontaneous seizures
coffee
Idioma Inglês
Data de publicação 2005-09-01
Publicado em Epilepsia. Oxford: Blackwell Publishing, v. 46, n. 9, p. 1401-1406, 2005.
ISSN 0013-9580 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing
Extensão 1401-1406
Fonte http://dx.doi.org/10.1111/j.1528-1167.2005.63904.x
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000231507100006
Endereço permanente http://repositorio.unifesp.br/handle/11600/28433

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