Five-year follow-up of patients with epidemic glomerulonephritis due to Streptococcus zooepidemicus

Five-year follow-up of patients with epidemic glomerulonephritis due to Streptococcus zooepidemicus

Autor Sesso, Ricardo Autor UNIFESP Google Scholar
Pinto, SWL Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Hosp Sao Joao Deus
Resumo Background. in 1998 there was a large outbreak of acute glomerulonephritis in Nova Serrana, Brazil, caused by group C Streptococcus zooepidemicus. This study describes the follow-up of these patients, after a mean time of 5.4 years of the acute episode.Methods. of 135 cases identified in 1998, 56 were re-examined in a prospective study and had measurements of blood pressure, creatinine clearance (estimated by the Cockcroft and Gault formula), microalbuminuria (radioimmunoassay), urine sediment analysis and a protein dipstick test.Results. of the original group of 135 subjects, 3 died in the acute phase and 5 (3.7 %) required chronic dialysis. of the 56 cases re-evaluated, 54 (96 %) were adults (mean +/- SD age, 43 +/- 17 years) and 36 (64 %) females. At the follow-up examination, we found arterial hypertension in 30 % (n = 17/56) of the subjects, reduced creatinine clearance (<80ml/min) in 49 % (n = 26/53) and increased microalbuminuria (> 20 mu g/min) in 22 % (n=11/51). Compared to the evaluation carried out 3 years before, the number of cases with creatinine clearance lower than 80ml/min increased from 20 to 26 (of 53 cases). Increased microalbuminuria and/or reduced creatinine clearance were detected in 57 % (n = 32/56) of the subjects. Patients with reduced creatinine clearance were older than those without reduced renal function (54 +/- 15 vs 34 +/- 12 years, P < 0.001).Conclusions. After a mean time of 5.4 years, a relatively high proportion of patients with epidemic poststreptococcal glomerulonephritis due to S.zooepidemicus present hypertension, reduced renal function and increased microalbuminuria.
Palavra-chave acute nephritis
epidemic nephritis
poststreptococcal glomerulonephritis
Streptococcus zooepidemicus
Idioma Inglês
Data de publicação 2005-09-01
Publicado em Nephrology Dialysis Transplantation. Oxford: Oxford Univ Press, v. 20, n. 9, p. 1808-1812, 2005.
ISSN 0931-0509 (Sherpa/Romeo, fator de impacto)
Publicador Oxford Univ Press
Extensão 1808-1812
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000231517900007
Endereço permanente

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