Electroacupuncture prevents cognitive deficits in pilocarpine-epileptic rats

Electroacupuncture prevents cognitive deficits in pilocarpine-epileptic rats

Autor Santos, J. G. dos Google Scholar
Tabosa, A. Google Scholar
Monte, FHM do Google Scholar
Blanco, M. M. Google Scholar
Freire, A. D. Google Scholar
Mello, L. E. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Here we investigated the effects of electroacupuncture over the cognitive deficits in the pilocarpine model of epilepsy in rats. Acupuncture stimulation was provided at acupoints located in either the midline of the back and of the head [HD]: Gv-20 (Baihui), Gv-14 (Dazhui), Gv-2 (Yaoshu) and M-HN-3 (Yin Tang); or acupoints located in the limbs [LB]: St-36 (Zusanli) and Sp-6 (Sanyinjiao). in the elevated T-maze test, electroacupuncture at HD and LB acupoints produced an improvement in the acquisition and retention parameters. Retention in the inhibitory avoidance test was seen only in short-term retention and only for animals stimulated at HD. At histology it was found that electroacupuncture at HD acupoints abolished tissue shrinkage in dorsal hippocampus, basolateral nucleus of the amygdala, substantia nigra and perirhinal cortex, whereas stimulation of LB acupoints prevented tissue shrinkage in all of the above structures except dorsal hippocampus. Administration of p-chlorophenylalanine, a serotonergic releaser, abolished both behavioral and part of the histological changes in these animals. We conclude that electroacupuncture at HD and LB acupoints prevents atrophy of some limbic structures and improves cognitive deficits in pilocarpine-epileptic rats and that this effect is dependent on the serotonergic system. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Palavra-chave electroacupuncture
temporal lobe epilepsy
learning
memory
rats
Idioma Inglês
Data de publicação 2005-08-26
Publicado em Neuroscience Letters. Clare: Elsevier B.V., v. 384, n. 3, p. 234-238, 2005.
ISSN 0304-3940 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 234-238
Fonte http://dx.doi.org/10.1016/j.neulet.2005.04.079
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000230463700006
Endereço permanente http://repositorio.unifesp.br/handle/11600/28426

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