Subjective memory complaints, white-matter lesions, depressive symptoms, and cognition in elderly patients

Subjective memory complaints, white-matter lesions, depressive symptoms, and cognition in elderly patients

Autor Minett, TSC Google Scholar
Dean, J. L. Google Scholar
Firbank, M. Google Scholar
English, P. Google Scholar
O'Brien, J. T. Google Scholar
Instituição Newcastle Gen Hosp
Universidade Federal de São Paulo (UNIFESP)
Resumo Objectives: Subjective memory complaints (SMC) and cerebral white-matter lesions (WML) are very prevalent among elderly subjects, but their clinical significance is controversial. the authors sought to determine whether SMCs are related to WML, independently of the presence of depressive symptoms, which are known to be associated with both. the relationship between SMC and cognition was also examined.Methods: This is a cross-sectional study on 60 elderly subjects without dementia. All subjects underwent FLAIR and T-2-weighted axial MRI scans, a memory-complaint questionnaire, a geriatric depression scale, and a comprehensive cognitive assessment.Results: Multiple linear regression showed that although the best correlate of SMC was the severity of depressive symptoms, SMC and WML were strongly correlated. Objective cognitive performance was not significantly associated with SMC after adjusting for WML and mood. the presence of a history of late-onset depression was a strong correlate of WML severity, even after adjusting for age, gender, and education.Conclusions: Complaints of cognitive decline are significantly associated with the severity of WML, independently of level of cognition and depression.
Idioma Inglês
Data de publicação 2005-08-01
Publicado em American Journal of Geriatric Psychiatry. Arlington: Amer Psychiatric Publishing, Inc, v. 13, n. 8, p. 665-671, 2005.
ISSN 1064-7481 (Sherpa/Romeo, fator de impacto)
Publicador Amer Psychiatric Publishing, Inc
Extensão 665-671
Fonte http://dx.doi.org/10.1097/00019442-200508000-00005
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000231020700005
Endereço permanente http://repositorio.unifesp.br/handle/11600/28420

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