Kinin and opioid receptors in the paratrigeminal nucleus modulate the somatosensory reflex to rat sciatic nerve stimulation

Kinin and opioid receptors in the paratrigeminal nucleus modulate the somatosensory reflex to rat sciatic nerve stimulation

Autor Koepp, J. Google Scholar
Caous, C. A. Google Scholar
Rae, G. A. Google Scholar
Balan, A. C. Google Scholar
Lindsey, C. J. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Santa Catarina (UFSC)
Resumo The influence of kinin and opioid receptor blockade in the paratrigeminal nucleus (Pa5) on the somatosensory reflex (SSR) to sciatic nerve stimulation (SNS) was assessed in anaesthetized-paralyzed rats. SNS (square 1 ms pulses at 0.6 mA and 20 Hz for 10 s) increased mean arterial pressure from 87 +/- 3 to 106 +/- 3 mmHg. Pressor responses to SNS were reduced 40-60% by HOE-140 and LF 16-0687 (B-2 receptor antagonists; 20 and 100 pmol respectively), CTOP or nor-binaltorphimine (mu and kappa opioid receptor antagonists, respectively; 1 mu g) but potentiated by naltrindole (delta opioid receptor antagonist) receptor antagonist microinjections into the contralateral (but not ipsilateral) Pa5. the SSR to sciatic nerve stimulation was not changed by B-1 kinin receptor or NK1, NK2 and NK3 tachykinin receptor antagonists administered to the Pa5. Capsaicin pretreatment (40 mg/kg/day, 3 days) abolished the effects of the opioid receptor antagonists, but did not change the effect of kinin B-2 receptor blockade on the SSR. Thus, the activity of B-2 and opioid receptor-operated mechanisms in the Pa5 contribute to the SSR in the rat, suggesting a role for these endogenous peptides in the cardiovascular responses to SNS. (c) 2005 Elsevier Inc. All rights reserved.
Palavra-chave bradykinin
blood pressure
capsaicin-sensitive fibers
cardiovascular reflex
sciatic nerve
nociception
Idioma Inglês
Data de publicação 2005-08-01
Publicado em Peptides. New York: Elsevier B.V., v. 26, n. 8, p. 1339-1345, 2005.
ISSN 0196-9781 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 1339-1345
Fonte http://dx.doi.org/10.1016/j.peptides.2005.03.033
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000231181700010
Endereço permanente http://repositorio.unifesp.br/handle/11600/28413

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