Kallikrein-kinin system in hepatic experimental models

Kallikrein-kinin system in hepatic experimental models

Autor Kouyoumdjian, M. Google Scholar
Nagaoka, M. R. Google Scholar
Borges, D. R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The purpose of this brief review is to describe some characteristics of the kallikrein-kinin system (KKS) in the liver. the liver synthesizes kininogens and prekallikrein and the synthesis of both proteins is increased in rats during the acute phase reaction. It is also the main organ to clear tissue as well as plasma kallikrein from the circulation in normal and pathological conditions. Bradykinin (BK), yielded by the kallikrein-kinin system, is a potent arterial hypotensive peptide, but in the liver it induces a portal hypertensive response. the portal hypertensive action of bradykinin is mediated by B2 receptors located on sinusoidal cells of the periportal region and is followed by its hydrolysis by angiotensin-converting enzyme, which is primarily present in the perivenous (centrolobular) region. (c) 2005 Elsevier Inc. All rights reserved.
Assunto kallikrein
portal hypertension
Idioma Inglês
Data 2005-08-01
Publicado em Peptides. New York: Elsevier B.V., v. 26, n. 8, p. 1301-1307, 2005.
ISSN 0196-9781 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 1301-1307
Fonte http://dx.doi.org/10.1016/j.peptides.2005.03.024
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000231181700005
URI http://repositorio.unifesp.br/handle/11600/28412

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