Behavioral characterization of morphine effects on motor activity in mice

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dc.contributor.author Patti, C. L.
dc.contributor.author Frussa, R.
dc.contributor.author Silva, R. H.
dc.contributor.author Carvalho, R. C.
dc.contributor.author Kameda, SR
dc.contributor.author Takatsu-Coleman, A. L.
dc.contributor.author Cunha, JLS
dc.contributor.author Abilio, V. C.
dc.date.accessioned 2016-01-24T12:38:00Z
dc.date.available 2016-01-24T12:38:00Z
dc.date.issued 2005-08-01
dc.identifier http://dx.doi.org/10.1016/j.pbb.2005.07.004
dc.identifier.citation Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 81, n. 4, p. 923-927, 2005.
dc.identifier.issn 0091-3057
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28411
dc.description.abstract A biphasic effect of morphine on locomotion has been extensively described. Nevertheless, the effects of this opioid on other behavioral parameters have been overlooked. the aim of the present study was to verify the effects of different doses of morphine on motor behaviors observed in an open-field. Adult female mice were injected with saline or morphine (10, 15 and 20 mg/kg, i.p.) and observed in an open-field for quantification of locomotor and rearing frequencies as well as duration of immobility and grooming. the lowest dose of morphine decreased locomotion (and increased immobility duration) while the highest dose increased it. All doses tested decreased rearing and grooming. Thus, the effects of morphine on locomotion do not parallel to its effects on rearing and grooming. Our results indicate that locomotion not always reflects the effect of drugs on motor activity, which can be better investigated when other behavioral parameters are concomitantly taken into account. (c) 2005 Elsevier Inc. All rights reserved. en
dc.format.extent 923-927
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Pharmacology Biochemistry and Behavior
dc.rights Acesso restrito
dc.subject morphine en
dc.subject motor behavior en
dc.subject open-field en
dc.subject mice en
dc.title Behavioral characterization of morphine effects on motor activity in mice en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Pharmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pharmacol, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1016/j.pbb.2005.07.004
dc.description.source Web of Science
dc.identifier.wos WOS:000231922500029



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