Behavioral characterization of morphine effects on motor activity in mice

Behavioral characterization of morphine effects on motor activity in mice

Author Patti, C. L. Google Scholar
Frussa, R. Google Scholar
Silva, R. H. Google Scholar
Carvalho, R. C. Google Scholar
Kameda, SR Google Scholar
Takatsu-Coleman, A. L. Google Scholar
Cunha, JLS Google Scholar
Abilio, V. C. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract A biphasic effect of morphine on locomotion has been extensively described. Nevertheless, the effects of this opioid on other behavioral parameters have been overlooked. the aim of the present study was to verify the effects of different doses of morphine on motor behaviors observed in an open-field. Adult female mice were injected with saline or morphine (10, 15 and 20 mg/kg, i.p.) and observed in an open-field for quantification of locomotor and rearing frequencies as well as duration of immobility and grooming. the lowest dose of morphine decreased locomotion (and increased immobility duration) while the highest dose increased it. All doses tested decreased rearing and grooming. Thus, the effects of morphine on locomotion do not parallel to its effects on rearing and grooming. Our results indicate that locomotion not always reflects the effect of drugs on motor activity, which can be better investigated when other behavioral parameters are concomitantly taken into account. (c) 2005 Elsevier Inc. All rights reserved.
Keywords morphine
motor behavior
open-field
mice
Language English
Date 2005-08-01
Published in Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 81, n. 4, p. 923-927, 2005.
ISSN 0091-3057 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 923-927
Origin http://dx.doi.org/10.1016/j.pbb.2005.07.004
Access rights Closed access
Type Article
Web of Science ID WOS:000231922500029
URI http://repositorio.unifesp.br/handle/11600/28411

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