Behavioral characterization of morphine effects on motor activity in mice

Behavioral characterization of morphine effects on motor activity in mice

Autor Patti, C. L. Google Scholar
Frussa, R. Google Scholar
Silva, R. H. Google Scholar
Carvalho, R. C. Google Scholar
Kameda, SR Google Scholar
Takatsu-Coleman, A. L. Google Scholar
Cunha, JLS Google Scholar
Abilio, V. C. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo A biphasic effect of morphine on locomotion has been extensively described. Nevertheless, the effects of this opioid on other behavioral parameters have been overlooked. the aim of the present study was to verify the effects of different doses of morphine on motor behaviors observed in an open-field. Adult female mice were injected with saline or morphine (10, 15 and 20 mg/kg, i.p.) and observed in an open-field for quantification of locomotor and rearing frequencies as well as duration of immobility and grooming. the lowest dose of morphine decreased locomotion (and increased immobility duration) while the highest dose increased it. All doses tested decreased rearing and grooming. Thus, the effects of morphine on locomotion do not parallel to its effects on rearing and grooming. Our results indicate that locomotion not always reflects the effect of drugs on motor activity, which can be better investigated when other behavioral parameters are concomitantly taken into account. (c) 2005 Elsevier Inc. All rights reserved.
Assunto morphine
motor behavior
Idioma Inglês
Data 2005-08-01
Publicado em Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 81, n. 4, p. 923-927, 2005.
ISSN 0091-3057 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 923-927
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000231922500029

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