HIV-1 superinfection is not a common event

HIV-1 superinfection is not a common event

Autor Diaz, R. S. Google Scholar
Pardini, R. Google Scholar
Catroxo, M. Google Scholar
Operskalski, E. A. Google Scholar
Mosley, J. W. Google Scholar
Busch, M. P. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ So Calif
Blood Ctr Pacific
Blood Syst Inc
Univ Calif San Francisco
Resumo Evidence for human immunodeficiency virus type 1 (HIV-1) superinfection was investigated among a group of four previously HIV-1 infected transfusion recipients (and the four implicated HIV-1 infected donors) identified by the Transfusion Safety Study, and two groups of 4 and 5 Brazilian injection drug users, who consistently injected themselves using shared paraphernalia. To probe these cases for possible superinfection we used heteroduplex mobility analysis (HMA) of HIV-1 tot, a technique which is a reliable for establishing epidemiologic linkages and searching for minor strains in mixed infection settings. in all these cases with established, untreated HIV-1 infections, we were unable to detect HIV-1 superinfection, even though the involved individuals were at high risk for second strain acquisition. We therefore conclude that although superinfection can occur in a few cases, it is a rare event, and the vast majority of recombinant HIV-1s characterized to date resulted from acute coinfections, rather than superinfection. (C) 2005 Elsevier B.V. All rights reserved.
Palavra-chave HIV-1 superinfection
intravenous exposure to HIV-1
injection drug users
heteroduplex mobility analysis
tat
Idioma Inglês
Data de publicação 2005-08-01
Publicado em Journal of Clinical Virology. Amsterdam: Elsevier B.V., v. 33, n. 4, p. 328-330, 2005.
ISSN 1386-6532 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 328-330
Fonte http://dx.doi.org/10.1016/j.jcv.2004.11.021
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000231136100012
Endereço permanente http://repositorio.unifesp.br/handle/11600/28407

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