Specific antibody levels in the aqueous humor and serum of two distinct populations of patients with ocular toxoplasmosis

Specific antibody levels in the aqueous humor and serum of two distinct populations of patients with ocular toxoplasmosis

Autor Garweg, J. G. Google Scholar
Ventura, ACS Google Scholar
Halberstadt, M. Google Scholar
Silveira, C. Google Scholar
Muccioli, C. Google Scholar
Belfort, R. Google Scholar
Jacquier, P. Google Scholar
Instituição Univ Bern
Universidade Federal de São Paulo (UNIFESP)
Erechim
ParaDiag
Resumo The population of Erechim, Southern Brazil, is characterized by a high incidence of ocular toxoplasmosis, which is presumed to be of acquired origin. We wished to compare the local specific humoral immune response of individuals from this region with that of Swiss patients suffering from the same disease. Paired samples of aqueous humor and serum were withdrawn from 27 Brazilian and 50 Swiss patients presenting consecutively with active ocular toxoplasmosis. the total and specific levels of IgG in each of these were determined. the populations did not differ with respect either to age or sex. the serum levels of total IgG in Brazilian (10.8 g/l) and Swiss patients (11.1 g/l) were similar (p = 0.499), but the aqueous humor ones were higher in the former group (95 vs. 20 mg/l; p = 0.0001). the systemic and local levels of specific IgG were likewise higher in Brazilian patients [206 i.u. vs. 72 i.u. (p = 0.001) and 14 i.u. vs. 4 i.u. (p = 0.005), respectively] and the number of individuals without detectable levels of local specific IgG was correspondingly lower (11% vs. 54%; p = 0.0005). the Goldmann-Witmer coefficient (an index of local specific antibody production) did not differ between Brazilian and Swiss patients (2.1 vs. 0.08, respectively; p = 0.107). Our findings are indicative of a more pronounced uveovascular barrier breakdown in Brazilians than in Swiss patients with active ocular toxoplasmosis. That the systemic and local specific immune response is weaker in Swiss than in Brazilian patients has not been hitherto documented. This finding may reflect differences in the immunological handling of the infection. (C) 2005 Elsevier GmbH. All rights reserved.
Palavra-chave ocular toxoplasmosis
local immune response
antibody coefficient
host-specific factors
population-based studies
Idioma Inglês
Data de publicação 2005-08-01
Publicado em International Journal of Medical Microbiology. Jena: Urban & Fischer Verlag, v. 295, n. 4, p. 287-295, 2005.
ISSN 1438-4221 (Sherpa/Romeo, fator de impacto)
Publicador Urban & Fischer Verlag
Extensão 287-295
Fonte http://dx.doi.org/10.1016/j.ijmm.2005.03.005
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000231698800010
Endereço permanente http://repositorio.unifesp.br/handle/11600/28405

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