Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains

Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains

Autor Sader, Helio S. Autor UNIFESP Google Scholar
Fritsche, Thomas R. Google Scholar
Kaniga, Kone Google Scholar
Ge, Yi Gong Google Scholar
Jones, Ronald N. Google Scholar
Instituição JMI Labs Inc
Universidade Federal de São Paulo (UNIFESP)
Peninsula Pharmaceut
Tufts Univ
Resumo PPI-0903M is a novel N-phosphono-type cephalosporin active against oxacillin-resistant staphylococci and many other gram-positive organisms. This study evaluated the in vitro activity and spectrum of PPI-0903M against 1,478 recent clinical isolates collected from 80 medical centers (22 countries). PPI-0903M demonstrated broader in vitro activity against gram-positive bacteria, particularly against multidrug-resistant staphylococci and streptococci of current clinical concern, than currently available extended-spectrum cephalosporins while maintaining similar activity against gram-negative pathogens.
Idioma Inglês
Data de publicação 2005-08-01
Publicado em Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 49, n. 8, p. 3501-3512, 2005.
ISSN 0066-4804 (Sherpa/Romeo, fator de impacto)
Publicador Amer Soc Microbiology
Extensão 3501-3512
Fonte http://dx.doi.org/10.1128/AAC.49.8.3501-3512.2005
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000230950700061
Endereço permanente http://repositorio.unifesp.br/handle/11600/28393

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