Leptin is not associated independently with hypertension in Japanese-Brazilian women

Leptin is not associated independently with hypertension in Japanese-Brazilian women

Autor Almeida-Pititto, Bianca de Autor UNIFESP Google Scholar
Gimeno, Suely Godoy Agostinho Autor UNIFESP Google Scholar
Freire, Renata Damiao Autor UNIFESP Google Scholar
Ribeiro-Filho, Fernando Flexa Autor UNIFESP Google Scholar
Ferreira, Sandra Roberta Gouvea Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo We evaluated the relationship of leptin with hypertension adjusted for body mass index (BMI) and/or waist circumference in a population of Japanese-Brazilian women aged> or = 30 years with centrally distributed adiposity. After excluding diabetic subjects, the study subjects - who participated in a population-based study on the prevalence of metabolic syndrome - showed prevalence rates of obesity (BMI> or = 25 kg/m²) and central adiposity (waist> or = 80 cm) of 32.0 and 37.8%, respectively. The hypertensive group (N = 162) was older, had higher BMI (24.9 ± 4.2 vs 23.3 ± 3.4 kg/m², P < 0.001), waist circumference (81.1 ± 10.1 vs 76.3 ± 8.2 cm, P < 0.001) and insulin levels (8.0 ± 6.2 vs 7.1 ± 4.9 µU/mL, P < 0.05) than the normotensive group (N = 322) and showed an unfavorable metabolic profile (higher 2-h plasma glucose, C-reactive protein and non-HDL cholesterol levels). Leptin did not differ between groups (8.2 ± 6.8 vs 7.2 ± 6.6 ng/mL, P = 0.09, for hypertensive vs normotensive, respectively) and its levels correlated significantly with anthropometric variables but not with blood pressure. Logistic regression analysis indicated that age and waist were independently associated with hypertension but not with homeostasis model assessment of insulin resistance or leptin levels. The lack of an independent association of hypertension with metabolic parameters (2-h glucose, C-reactive protein and non-HDL cholesterol) after adjustment for central adiposity suggested that visceral fat deposition may be the common mediator of the disturbances of the metabolic syndrome. Our data indicate that age and waist are major determinants of hypertension in this population of centrally obese (waist> or = 80 cm) Japanese-Brazilian women, but do not support a role for leptin in the elevation of blood pressure.
Palavra-chave Hypertension
Body fat distribution
Insulin
Leptin
Centrally obese
Metabolic syndrome
Idioma Inglês
Data de publicação 2006-01-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 1, p. 99-105, 2006.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 99-105
Fonte http://dx.doi.org/10.1590/S0100-879X2006000100012
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000235089500012
SciELO S0100-879X2006000100012 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/2839

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