Effect of dietary supplementation with vitamin E and stocking density on macrophage recruitment and giant cell formation in the teleost fish, Piaractus mesopotamicus

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dc.contributor.author Belo, MAA
dc.contributor.author Schalch, SHC
dc.contributor.author Moraes, F. R.
dc.contributor.author Soares, V. E.
dc.contributor.author Otoboni, AMMB
dc.contributor.author Moraes, JER
dc.date.accessioned 2016-01-24T12:37:58Z
dc.date.available 2016-01-24T12:37:58Z
dc.date.issued 2005-08-01
dc.identifier http://dx.doi.org/10.1016/j.jcpa.2005.04.004
dc.identifier.citation Journal of Comparative Pathology. London: Academic Press Ltd Elsevier B.V., v. 133, n. 2-3, p. 146-154, 2005.
dc.identifier.issn 0021-9975
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28387
dc.description.abstract The effect of dietary supplementation with 0, 100 and 450 mg of vitamin E (DL-alpha tocopheryl acetate)/kg of a dry diet on the kinetics of macrophage recruitment and giant cell formation in the pacu, maintained at different stocking densities (5 kg/m(3) and 20 kg/m(3)), was investigated by insertion of round glass coverslips into the subcutaneous connective tissue. After a feeding period of 18 weeks, the coverslips were implanted and later removed for examination at 2, 7 and 15 days post-implantation. Fish fed diets supplemented with 450 mg of vitamin E showed an increase (P < 0.05) in the accumulation of macrophages, foreign body giant cells and Langhans type cells. the kinetics of macrophage recruitment and giant cell formation on the glass coverslips appeared to be strongly influenced by vitamin E supplementation, since fish fed a basal diet and held at high stocking densities showed low numbers of adhering cells on the coverslips, and high concentrations of plasma corticosteroids. On the other hand, fish given a diet supplemented with 450 mg of vitamin E did not show a similar difference in plasma cortisol concentrations related to stocking density. the effect of cortisol concentrations on carbohydrate metabolism, analysed by assessment of plasma glycaemia, was not clear. Blood glucose concentrations did not vary substantially with the different treatments examined. These results suggest that vitamin E may contribute to the efficiency of the fish's inflammatory response by increasing macrophage recruitment and giant cell formation in the foreign body granulomatous reaction. Vitamin E appeared to act on the stress response of pacus by preventing a stress-related immunosuppression. (c) 2005 Elsevier B.V. All rights reserved. en
dc.format.extent 146-154
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Journal of Comparative Pathology
dc.rights Acesso aberto
dc.subject alpha-tocopherol en
dc.subject cortisol en
dc.subject fish en
dc.subject Piaractus mesopotamicus en
dc.subject polykaryon macrophage en
dc.subject vitamin E en
dc.title Effect of dietary supplementation with vitamin E and stocking density on macrophage recruitment and giant cell formation in the teleost fish, Piaractus mesopotamicus en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Vet Pathol, Jaboticabal, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Technol, Jaboticabal, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Aquaculture Ctr, Jaboticabal, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Vet Pathol, Jaboticabal, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Technol, Jaboticabal, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Aquaculture Ctr, Jaboticabal, Brazil
dc.identifier.doi 10.1016/j.jcpa.2005.04.004
dc.description.source Web of Science
dc.identifier.wos WOS:000231570300007



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