The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease

The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease

Autor El-Sayed, N. M. Google Scholar
Myler, P. J. Google Scholar
Bartholomeu, D. C. Google Scholar
Nilsson, D. Google Scholar
Aggarwal, G. Google Scholar
Tran, A. N. Google Scholar
Ghedin, E. Google Scholar
Worthey, E. A. Google Scholar
Delcher, A. L. Google Scholar
Blandin, G. Google Scholar
Westenberger, S. J. Google Scholar
Caler, E. Google Scholar
Cerqueira, G. C. Google Scholar
Branche, C. Google Scholar
Haas, B. Google Scholar
Anupama, A. Google Scholar
Arner, E. Google Scholar
Aslund, L. Google Scholar
Attipoe, P. Google Scholar
Bontempi, E. Google Scholar
Bringaud, F. Google Scholar
Burton, P. Google Scholar
Cadag, E. Google Scholar
Campbell, D. A. Google Scholar
Carrington, M. Google Scholar
Crabtree, J. Google Scholar
Darban, H. Google Scholar
Silveira, J. F. da Google Scholar
Jong, P. de Google Scholar
Edwards, K. Google Scholar
Englund, P. T. Google Scholar
Fazelina, G. Google Scholar
Feldblyum, T. Google Scholar
Ferella, M. Google Scholar
Frasch, A. C. Google Scholar
Gull, K. Google Scholar
Horn, D. Google Scholar
Hou, L. H. Google Scholar
Huang, Y. T. Google Scholar
Kindlund, E. Google Scholar
Ktingbeil, M. Google Scholar
Kluge, S. Google Scholar
Koo, H. Google Scholar
Lacerda, D. Google Scholar
Levin, M. J. Google Scholar
Lorenzi, H. Google Scholar
Louie, T. Google Scholar
Machado, C. R. Google Scholar
McCulloch, R. Google Scholar
McKenna, A. Google Scholar
Mizuno, Y. Google Scholar
Mottram, J. C. Google Scholar
Nelson, S. Google Scholar
Ochaya, S. Google Scholar
Osoegawa, K. Google Scholar
Pai, G. Google Scholar
Parsons, M. Google Scholar
Pentony, M. Google Scholar
Pettersson, U. Google Scholar
Pop, M. Google Scholar
Ramirez, J. L. Google Scholar
Rinta, J. Google Scholar
Robertson, L. Google Scholar
Salzberg, S. L. Google Scholar
Sanchez, D. O. Google Scholar
Seyler, A. Google Scholar
Sharma, R. Google Scholar
Shetty, J. Google Scholar
Simpson, A. J. Google Scholar
Sisk, E. Google Scholar
Tammi, M. T. Google Scholar
Tarteton, R. Google Scholar
Teixeira, S. Google Scholar
Van Aken, S. Google Scholar
Vogt, C. Google Scholar
Ward, P. N. Google Scholar
Wickstead, B. Google Scholar
Wortman, J. Google Scholar
White, O. Google Scholar
Fraser, C. M. Google Scholar
Stuart, K. D. Google Scholar
Andersson, B. Google Scholar
Instituição Inst Genome Res
George Washington Univ
Seattle Biomed Res Inst
Univ Washington
Karolinska Inst
Univ Calif Los Angeles
Universidade Federal de Minas Gerais (UFMG)
Uppsala Univ
Adm Nacl Labs
Inst Salud ANUS
Univ Bordeaux 2
Univ Glasgow
Univ Cambridge
Universidade Federal de São Paulo (UNIFESP)
Childrens Hosp
Johns Hopkins Univ
Natl Univ San Martin
CNR
Univ Oxford
Univ London London Sch Hyg & Trop Med
Univ Massachusetts
Fundacao Oswaldo Cruz
Univ Buenos Aires
Cent Univ Venezuela
ADEA MCT
Natl Univ Singapore
Univ Georgia
Resumo Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large, families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
Idioma Inglês
Data de publicação 2005-07-15
Publicado em Science. Washington: Amer Assoc Advancement Science, v. 309, n. 5733, p. 409-415, 2005.
ISSN 0036-8075 (Sherpa/Romeo, fator de impacto)
Publicador Amer Assoc Advancement Science
Extensão 409-415
Fonte http://dx.doi.org/10.1126/science.1112631
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000230574900035
Endereço permanente http://repositorio.unifesp.br/handle/11600/28386

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