Cognitive enhancement in aged rats after chronic administration of Equisetum arvense L. with demonstrated antioxidant properties in vitro

Cognitive enhancement in aged rats after chronic administration of Equisetum arvense L. with demonstrated antioxidant properties in vitro

Autor Santos, J. G. dos Google Scholar
Hoffmann, F. Google Scholar
Martins, D. do Google Scholar
Blanco, M. M. Google Scholar
Lanziotti, VMDB Google Scholar
Maia, F. D. Google Scholar
Leal, LKD Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Santa Catarina (UFSC)
Fed Univ Ceara
Resumo The aim of this work was to verify if chronic administration of the hydroalcoholic extract of stems from Equisetum arvense (HAE) reverses the cognitive impairment in aged rats, as well as, evaluates it in vitro antioxidant properties. Chronic administration of HAE at dose of 50 mg/kg, i.p., improved both short- and long-term retention of inhibitory avoidance task and ameliorated the cognitive performance in reference and working memory version of the Morris Water Maze. No differences were found between all three groups of young controls, aged controls and EHA-treated animals with regard to the open field and elevated plus maze tests. Indeed, no toxicity manifestations were observed during treatment. in vitro assays revealed that HAE diminished the thiobarbituric acid reactive substances as well as nitrite formation, but did not alter catalase activity. Thus, the cognitive enhancement effects of the HAE may be attributed, at least in part, to it antioxidant action. (c) 2005 Elsevier Inc. All rights reserved.
Palavra-chave equisetum arvense
learning
memory
aging
oxidative stress
Idioma Inglês
Data de publicação 2005-07-01
Publicado em Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 81, n. 3, p. 593-600, 2005.
ISSN 0091-3057 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 593-600
Fonte http://dx.doi.org/10.1016/j.pbb.2005.04.012
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000230970400022
Endereço permanente http://repositorio.unifesp.br/handle/11600/28375

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta