Cold stimulus-fingertip lacticemy: Standardization of the test in normal volunteers and diagnostic application for systemic sclerosis

Cold stimulus-fingertip lacticemy: Standardization of the test in normal volunteers and diagnostic application for systemic sclerosis

Autor Kayser, C. Google Scholar
Pucinelli, MLC Google Scholar
Fontenelle, SMA Google Scholar
Andrade, LEC Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Objectives: To standardize the cold stimulus-fingertip lacticemy test (CS-FTL) in normal individuals and to establish reference levels for discrimination of normal individuals and patients with systemic sclerosis (SSc).Methods: FTL was determined before (pre-CS) and 3, 8, and 13 min after cold stimulus (post-CS) in 94 normal controls according to gender and age. Diagnostic performance of Delta CS-FTL (percentage difference between post- and pre-CS-FTL) was tested comparing 25 SSc patients and the 94 normal individuals by ROC curve analysis.Results: Successive FTL determinations in the same fingertip yielded consistent results and the whole CS-FTL test proved to be reproducible. Pre-CS-FTL in SSc patients was higher than in normal controls (P < 0.001). FTL decreased after cold stimulus (negative Delta CS-FTL) in normal controls while SSc patients presented positive ACS-FTL. Gender did not influence pre-CS-FTL and post-CS-FTL in normal controls. the decrease in FTL after cold stimulus was more prominent for normal individuals between 25 and 34 years old in comparison to other age subgroups, with statistical significance for females at 3 min post-CS (P < 0.05). ROC curve analysis showed better diagnostic performance with post-CS-FTL at 8 and 13 min.Conclusion: CS-FTL test provides a reproducible quantitative biochemical parameter that reflects fingertip microcirculation status and was able to discriminate patients with SSc and normal controls, with optimal performance with post-CS-FTL at 8 to 13 min. (c) 2005 Elsevier Inc. All rights reserved.
Palavra-chave Raynaud's disease
systemic sclerosis
lacticemy
microcirculation
Idioma Inglês
Data de publicação 2005-07-01
Publicado em Microvascular Research. San Diego: Academic Press Inc Elsevier Science, v. 70, n. 1-2, p. 84-89, 2005.
ISSN 0026-2862 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 84-89
Fonte http://dx.doi.org/10.1016/j.mvr.2005.04.004
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000233386800010
Endereço permanente http://repositorio.unifesp.br/handle/11600/28374

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