Long-term cosequences of intrahippocampal kainate injection in the Proechimys guyannensis rodent

Long-term cosequences of intrahippocampal kainate injection in the Proechimys guyannensis rodent

Autor Arida, R. M. Google Scholar
Scorza, F. A. Google Scholar
Carvalho, R. D. Google Scholar
Cavalheiro, E. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Morgi Cruzes
Resumo The Proechimys guyannensis (PG), a spiny rodent specie living in the Amazonian region has been recently studied as an animal model of anti-convulsant mechanisms. the PG was found to be resistant to the administration of the muscarinic cholinergic agonist pilocarpine or the amygdala kindling development. This study examined the susceptibility of this animal species to the intrahippocampal kainic acid (KA) injection. Electrographic, behavioral and neuropathological changes induced by intrahippocampal KA injections were analyzed. PG showed to be extremely sensitive to the acute effects of the KA injection. Although the EEG findings in PG rodents were similar to those typically obtained in Wistar rats the pattern of electrographic activity in PG animals was longer than in Wistar rats. Neuropathological examinations of PG brains that survived KA-induced SE revealed severe cell loss in CA1/CA3 areas of the hippocampus, an extensive cell dispersion in the hilus of DG at the injected site with mossy fiber sprouting in the dentate gyrus supragranular layer. None of PG animals presented spontaneous seizures during the 120 days of observation. These findings confirm our previous observation on the resistance of this animal specie to experimental models of limbic epilepsy. (c) 2005 Elsevier B.V. All rights reserved.
Palavra-chave epilepsy
kainic acid
Proechimys guyannensis
Idioma Inglês
Data de publicação 2005-07-01
Publicado em Epilepsy Research. Amsterdam: Elsevier B.V., v. 65, n. 3, p. 201-210, 2005.
ISSN 0920-1211 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 201-210
Fonte http://dx.doi.org/10.1016/j.eplepsyres.2005.07.001
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000231936600009
Endereço permanente http://repositorio.unifesp.br/handle/11600/28372

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