Genetic polymorphism in the sulfotransferase SULT1A1 gene in cancer

Genetic polymorphism in the sulfotransferase SULT1A1 gene in cancer

Autor Pereira, W. O. Google Scholar
Paiva, A. S. Google Scholar
Queiroz, J. W. Google Scholar
Toma, L. Google Scholar
Dietrich, C. P. Google Scholar
Nader, H. B. Google Scholar
Jeronimo, SMB Google Scholar
Instituição Univ Fed Rio Grande Norte
Universidade Federal de São Paulo (UNIFESP)
Resumo Cytosolic sulfotransferases are enzymes that catalyze the conjugation of sulfate groups to a variety of xenobiotic and endogenous substrates. A mutation in the SULT1A1 gene has been associated with decreased sulfotransferase activity. We studied 125 cancer patients and 100 healthy controls from Brazil matched by age and gender. the objective of this study was to assess the impact of the SULT1A1 polymorphism on sulfotransferase activity in a population of cancer patients. Both heterozygous and homozygous individuals for the mutant allele had significantly decreased sulfotransferase enzymatic activity. This decrease was more significant in cancer patients. the frequency of the SULT1A1*2 allele was increased in the myeloma group (odds ratio = 0.53). These data suggest a functional role for the SULT1A1 gene polymorphism in cancer. (c) 2005 Elsevier Inc. All rights reserved.
Idioma Inglês
Data de publicação 2005-07-01
Publicado em Cancer Genetics and Cytogenetics. New York: Elsevier B.V., v. 160, n. 1, p. 55-60, 2005.
ISSN 0165-4608 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 55-60
Fonte http://dx.doi.org/10.1016/j.cancergencyto.2004.12.005
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000230221100008
Endereço permanente http://repositorio.unifesp.br/handle/11600/28369

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