Surgically amenable epilepsies in children and adolescents: clinical, imaging, electrophysiological, and post-surgical outcome data

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dc.contributor.author Terra-Bustamante, V. C.
dc.contributor.author Fernandes, RMF
dc.contributor.author Inuzuka, L. M.
dc.contributor.author Velasco, T. R.
dc.contributor.author Alexandre, V
dc.contributor.author Wichert-Ana, L.
dc.contributor.author Funayama, S.
dc.contributor.author Garzon, E.
dc.contributor.author Santos, A. C.
dc.contributor.author Araujo, D.
dc.contributor.author Walz, R.
dc.contributor.author Assirati, J. A.
dc.contributor.author Machado, H. R.
dc.contributor.author Sakamoto, A. C.
dc.date.accessioned 2016-01-24T12:37:56Z
dc.date.available 2016-01-24T12:37:56Z
dc.date.issued 2005-07-01
dc.identifier http://dx.doi.org/10.1007/s00381-004-1106-0
dc.identifier.citation Childs Nervous System. New York: Springer, v. 21, n. 7, p. 546-551, 2005.
dc.identifier.issn 0256-7040
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28363
dc.description.abstract Background and purpose: A large number of patients with epilepsy in the pediatric population have medically intractable epilepsy. in this age group seizures are usually daily or weekly, and response to antiepileptic therapy is poor, especially for those with neurological abnormalities and symptomatic epilepsies. However, several authors have already demonstrated similarly favorable long-term post-surgical seizure control when comparing pediatric and adult populations. in this article we aim to report the experience of the Ribeirao Preto Epilepsy Surgery Program in pediatric epilepsy surgery. Patients and methods: We analyzed 107 patients with medically intractable epilepsy operated on between July 1994 and December 2002, considering age at surgery, seizure type, pathological findings, and seizure outcome. All data were prospectively collected according to protocols previously approved by the institution ethics committee. Results: We analyzed a total of 115 operations performed in 107 patients. There was no difference in sex distribution. Complex partial seizures occurred in 31.4% of the patients, followed by tonic seizures (25.9%), focal motor seizures (15.4%), and infantile spasms (13.3%). the most common etiologies were cortical developmental abnormalities (25.2%), tumors (16.8%), mesial temporal sclerosis (15.9%), Rasmussen syndrome (6.5%), and tuberous sclerosis (6.5%). Overall post-surgical seizure outcome showed 67.2% of the patients within Engel classes I and II, reaching 75.0% when patients with callosotomies were excluded. Conclusions: Post-surgical seizure control in the pediatric population is similar to that in adult patients, despite the fact that epilepsies in this age group are more frequently of extratemporal origin, suggesting that surgery should be considered in children as soon as intractability is determined. en
dc.format.extent 546-551
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Childs Nervous System
dc.rights Acesso restrito
dc.subject intractable epilepsy en
dc.subject pediatric epilepsy en
dc.subject epilepsy surgery en
dc.title Surgically amenable epilepsies in children and adolescents: clinical, imaging, electrophysiological, and post-surgical outcome data en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ São Paulo, Ribeirao Preto Sch Med, Dept Neurol, BR-14049900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Ribeirao Preto Sch Med, Dept Radiol, BR-14049900 São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Ribeirao Preto Sch Med, Dept Neurosurg, BR-14049900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil
dc.identifier.doi 10.1007/s00381-004-1106-0
dc.description.source Web of Science
dc.identifier.wos WOS:000230624300006



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