Protective effects of a etoricoxib, a selective inhibitor of cyclooxygenase-2, in experimental periodontitis in rats

Protective effects of a etoricoxib, a selective inhibitor of cyclooxygenase-2, in experimental periodontitis in rats

Author Holzhausen, M. Google Scholar
Spolidorio, DMP Google Scholar
Muscara, M. N. Google Scholar
Hebling, J. Google Scholar
Spolidorio, L. C. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Background: the purpose of the present study was to evaluate the effect of a potent selective cyclooxygenase-2 (COX-2) inhibitor, etoricoxib, on the prevention of alveolar bone loss in experimental periodontitis induced in rats.Methods: Ninety Wistar rats were separated into three experimental groups. Cotton ligatures were placed at the gingival margin level of lower right first molars. the rats were randomly assigned to one of the following groups: control received a daily oral dose of 1 ml/kg of saline solution; Etol received 6 mg/kg of etoricoxib; Eto2 received 12 mg/kg of etoricoxib. Serum levels of etoricoxib and white blood cells were determined. Standardized digital radiographs were taken after death at 3, 5, 10, 18 and 30 days to measure the amount of bone loss at the mesial root surface of the first molar tooth in each rat.Results: One-way analysis of variance (ANOVA) indicated that groups treated with both doses of etoricoxib had significantly (p < 0.05) less alveolar bone loss when compared to controls. Furthermore, etoricoxib treatment significantly inhibited the leukocytosis observed 3 days after the induction of periodontitis.Conclusion: These data provide evidence that systemic therapy with etoricoxib can retard alveolar bone loss in a ligature-induced periodontitis model in rats.
Keywords alveolar bone loss
prevention
control
cyclooxygenase inhibitors
periodontitis
Language English
Date 2005-06-01
Published in Journal of Periodontal Research. Frederiksberg C: Blackwell Munksgaard, v. 40, n. 3, p. 208-211, 2005.
ISSN 0022-3484 (Sherpa/Romeo, impact factor)
Publisher Blackwell Munksgaard
Extent 208-211
Origin http://dx.doi.org/10.1111/j.1600-0765.2005.00787.x
Access rights Closed access
Type Article
Web of Science ID WOS:000229071200003
URI http://repositorio.unifesp.br/handle/11600/28338

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