Relationship between histopathological features of chemotherapy treated retinoblastorna and P-glycoprotein expression

Relationship between histopathological features of chemotherapy treated retinoblastorna and P-glycoprotein expression

Autor Souza, J. P. Google Scholar
Martins, M. C. Google Scholar
Caissie, A. L. Google Scholar
Torres, VLL Google Scholar
Fernandes, LHCF Google Scholar
Erwenne, C. M. Google Scholar
Burnier, M. N. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
McGill Univ
Resumo Background: P-glycoprotein (P-gp) has been identified as a possible mediator of chemoresistance in retinoblastoma. the aim of this study was to determine the expression of P-gp in retinoblastoma treated with chemotherapy prior to enucleation.Methods: Seventeen enucleated specimens of retinoblastoma from 16 patients were studied. Nine had been treated with chemotherapy alone, and eight had been treated with chemotherapy and other forms of local treatment. Tumour differentiation as well as choroidal and optic nerve invasion were assessed. P-gp immunohistochemical staining was performed and evaluated as negative, low or high.Results: Histopathological assessment of the cases showed that 14 of 17 eyes (82.3%) had viable retinoblastoma cells. Nine retinoblastomas were considered regressed with a well-differentiated component, five regressed retinoblastomas had viable cells with poor differentiation and three retinoblastomas had regressed leaving no viable cells. Sixteen of 17 retinoblastomas were P-gp positive. in the one case with optic nerve invasion and the three cases with massive choroidal invasion, P-gp expression was found in invading retinoblastoma cells.Conclusion: Almost all retinoblastomas expressed P-gp. High levels of P-gp expression might play a role in chemotherapy resistance of retinoblastoma or, conversely, chemotherapy might induce P-gp expression. These results might have an impact on management of bilateral retinoblastoma.
Palavra-chave chemotherapy
histopathology
immunohistochemistry
P-glycoprotein
retinoblastoma
Idioma Inglês
Data de publicação 2005-06-01
Publicado em Clinical and Experimental Ophthalmology. Oxford: Blackwell Publishing, v. 33, n. 3, p. 279-284, 2005.
ISSN 1442-6404 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing
Extensão 279-284
Fonte http://dx.doi.org/10.1111/j.1442-9071.2005.00991.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000230168600010
Endereço permanente http://repositorio.unifesp.br/handle/11600/28337

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