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Title: Cytotoxic lignans from the stems of Styrax camporum (Styracaceae)
Authors: Teles, H. L.
Hemerly, J. P.
Pauletti, P. M.
Pandolfi, JRC
Araujo, A. R.
Valentini, SR
Young, MCM
Bolzani, V. D.
Silva, DHS
Universidade Federal de São Paulo (UNIFESP)
Inst Bot
Keywords: Styrax camporum
cytotoxic lignans
MTT assay
Issue Date: 1-Jun-2005
Publisher: Taylor & Francis Ltd
Citation: Natural Product Research. Abingdon: Taylor & Francis Ltd, v. 19, n. 4, p. 319-323, 2005.
Abstract: An ethanolic extract from the stems of Styrax camporum Pohl (Styracaceae), a plant traditionally used for gastrointestinal diseases, was fractionated and subjected to flash chromatography and afforded two benzofuran lignans, egonol and homoegonol, and one furofuran lignan, (+/-) syringaresinol, which were identified by spectral data interpretation. Their cytotoxic activities against Hep-2 (larynx epidermoid carcinoma), HeLa (human cervix carcinoma) and C6 (rat glioma) cell lines were evaluated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay at several concentrations for 24 h. Activities could be observed for egonol against C6 (IC50 = 3.2 mu g/mL) and Hep-2 (IC50 = 3.6 mu g/mL) cell lines, and for homoegonol against C6 (IC50 = 4.9 mu g/mL) and HeLa (IC50 =- 5.3 mu g/mL) cells.
ISSN: 1478-6419
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