Cytotoxic lignans from the stems of Styrax camporum (Styracaceae)

Mostrar registro simples Teles, H. L. Hemerly, J. P. Pauletti, P. M. Pandolfi, JRC Araujo, A. R. Valentini, SR Young, MCM Bolzani, V. D. Silva, DHS 2016-01-24T12:37:54Z 2016-01-24T12:37:54Z 2005-06-01
dc.identifier.citation Natural Product Research. Abingdon: Taylor & Francis Ltd, v. 19, n. 4, p. 319-323, 2005.
dc.identifier.issn 1478-6419
dc.description.abstract An ethanolic extract from the stems of Styrax camporum Pohl (Styracaceae), a plant traditionally used for gastrointestinal diseases, was fractionated and subjected to flash chromatography and afforded two benzofuran lignans, egonol and homoegonol, and one furofuran lignan, (+/-) syringaresinol, which were identified by spectral data interpretation. Their cytotoxic activities against Hep-2 (larynx epidermoid carcinoma), HeLa (human cervix carcinoma) and C6 (rat glioma) cell lines were evaluated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay at several concentrations for 24 h. Activities could be observed for egonol against C6 (IC50 = 3.2 mu g/mL) and Hep-2 (IC50 = 3.6 mu g/mL) cell lines, and for homoegonol against C6 (IC50 = 4.9 mu g/mL) and HeLa (IC50 =- 5.3 mu g/mL) cells. en
dc.format.extent 319-323
dc.language.iso eng
dc.publisher Taylor & Francis Ltd
dc.relation.ispartof Natural Product Research
dc.rights Acesso restrito
dc.subject Styrax camporum en
dc.subject Styracaceae en
dc.subject cytotoxic lignans en
dc.subject MTT assay en
dc.title Cytotoxic lignans from the stems of Styrax camporum (Styracaceae) en
dc.type Artigo
dc.contributor.institution UNESP
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Inst Bot
dc.description.affiliation UNESP, Inst Quim, BR-14800900 Araraquara, Brazil
dc.description.affiliation UNIFESP, Escola Paulista Med, BR-14801902 Araraquara, Brazil
dc.description.affiliation UNESP, Fac Ciencias Farmaceut, BR-14801902 Araraquara, Brazil
dc.description.affiliation Inst Bot, Secao Fisiol & Bioquim Plantas, BR-01061970 São Paulo, Brazil
dc.description.affiliationUnifesp UNIFESP, Escola Paulista Med, BR-14801902 Araraquara, Brazil
dc.identifier.doi 10.1080/14786410412331271979
dc.description.source Web of Science
dc.identifier.wos WOS:000229394900003

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