Cytotoxic lignans from the stems of Styrax camporum (Styracaceae)

Cytotoxic lignans from the stems of Styrax camporum (Styracaceae)

Autor Teles, H. L. Google Scholar
Hemerly, J. P. Google Scholar
Pauletti, P. M. Google Scholar
Pandolfi, JRC Google Scholar
Araujo, A. R. Google Scholar
Valentini, SR Google Scholar
Young, MCM Google Scholar
Bolzani, V. D. Google Scholar
Silva, DHS Google Scholar
Instituição UNESP
Universidade Federal de São Paulo (UNIFESP)
Inst Bot
Resumo An ethanolic extract from the stems of Styrax camporum Pohl (Styracaceae), a plant traditionally used for gastrointestinal diseases, was fractionated and subjected to flash chromatography and afforded two benzofuran lignans, egonol and homoegonol, and one furofuran lignan, (+/-) syringaresinol, which were identified by spectral data interpretation. Their cytotoxic activities against Hep-2 (larynx epidermoid carcinoma), HeLa (human cervix carcinoma) and C6 (rat glioma) cell lines were evaluated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay at several concentrations for 24 h. Activities could be observed for egonol against C6 (IC50 = 3.2 mu g/mL) and Hep-2 (IC50 = 3.6 mu g/mL) cell lines, and for homoegonol against C6 (IC50 = 4.9 mu g/mL) and HeLa (IC50 =- 5.3 mu g/mL) cells.
Palavra-chave Styrax camporum
Styracaceae
cytotoxic lignans
MTT assay
Idioma Inglês
Data de publicação 2005-06-01
Publicado em Natural Product Research. Abingdon: Taylor & Francis Ltd, v. 19, n. 4, p. 319-323, 2005.
ISSN 1478-6419 (Sherpa/Romeo, fator de impacto)
Publicador Taylor & Francis Ltd
Extensão 319-323
Fonte http://dx.doi.org/10.1080/14786410412331271979
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000229394900003
Endereço permanente http://repositorio.unifesp.br/handle/11600/28333

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