Incidence of congenital toxoplasmosis estimated by neonatal screening: relevance of diagnostic confirmation in asymptomatic newborn infants

Incidence of congenital toxoplasmosis estimated by neonatal screening: relevance of diagnostic confirmation in asymptomatic newborn infants

Autor Carvalheiro, C. G. Google Scholar
Mussi-Pinhata, M. M. Google Scholar
Yamamoto, A. Y. Google Scholar
De Souza, CBS Google Scholar
Maciel, LMZ Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Congenital toxoplasmosis is rarely identified by routine clinical examination. the aim of this study was to estimate the incidence of the disease in the region of Ribeirao Preto, south-eastern Brazil. A definitive diagnosis was made on the basis of the persistence of anti-Toxoplasma IgG antibodies beyond I year of age. Blood samples obtained from 15 162 neonates and adsorbed onto filter paper were tested for anti-Toxoplasma IgM antibodies. Fifteen samples gave positive results. A definitive diagnosis was confirmed in five of the 13 infants (38.5%) who completed follow-up. These five infants presented with serum IgM and/or IgA antibodies, and clinical abnormalities. Disease incidence was estimated to be 3.3/10000 (95% CI 1.0-7.7), indicating the need for preventive measures. Neonatal screening is feasible, but screening tests with a better performance are required; positive screening results must be carefully confirmed.
Idioma Inglês
Data de publicação 2005-06-01
Publicado em Epidemiology and Infection. New York: Cambridge Univ Press, v. 133, n. 3, p. 485-491, 2005.
ISSN 0950-2688 (Sherpa/Romeo, fator de impacto)
Publicador Cambridge Univ Press
Extensão 485-491
Fonte http://dx.doi.org/10.1017/S095026880400353X
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000230079000012
Endereço permanente http://repositorio.unifesp.br/handle/11600/28331

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