Lack of impact of hepatitis c virus coinfection in end-stage renal disease patients with hepatitis B virus infection

Lack of impact of hepatitis c virus coinfection in end-stage renal disease patients with hepatitis B virus infection

Autor Moutinho, R. S. Google Scholar
Perez, R. M. Google Scholar
Pace, FHL Google Scholar
Ferreira, ASP Google Scholar
Cendoroglo, M. Google Scholar
Medina-Pestana, J. O. Google Scholar
Lanzoni, V. P. Google Scholar
Silva, AEB Google Scholar
Ferraz, MLG Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Resumo Introduction. Hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection results in more severe forms of liver disease in nonuremic patients; however, the impact of HCV coinfection is not clearly known in end-stage renal disease (ESRD) patients with HBV infection. We sought to determine the impact of HCV coinfection in UBV-infected ESRD patients.Patients and Methods. the HBsAg-positive ESRD patients evaluated between March 1999 and May 2003 were divided into two groups: group B, HBV infection alone, and group BC, HBV-HCV coinfection (anti-HCV-positive). Both groups were compared regarding epidemiological, laboratory, and histological findings. A liver biopsy was obtained in cases with evidence of viral replication and/or elevated alanine aminotransferase.Results. One hundred patients (73% men) with mean age of 42 +/- 11 years (55 patients in group B and 45 in group BC) were studied. Comparison between groups showed a difference in time on hemodialysis and duration of infection, which were higher in group BC (P < .001 and P = .001, respectively) and in history of blood transfusion, which was also more frequent in group BC (P = .04). Liver biopsies, obtained from 15 patients in group B and 28 patients in group BC, showed no difference in frequency of septal fibrosis (60% in group B vs 48% in group BC, P = .46) or interface hepatitis (73% vs 71%, P = .99).Conclusions. HBV-HCV coinfection was related to a longer time on hemodialysis, longer duration of infection, and history of blood transfusion. Contrary to nonuremic patients, HCV coinfection was not associated with more severe forms of liver disease in ESRD patients.
Idioma Inglês
Data de publicação 2005-06-01
Publicado em Transplantation Proceedings. New York: Elsevier B.V., v. 37, n. 5, p. 2080-2082, 2005.
ISSN 0041-1345 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 2080-2082
Fonte http://dx.doi.org/10.1016/j.transproceed.2005.03.002
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000230024800027
Endereço permanente http://repositorio.unifesp.br/handle/11600/28329

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