Beneficial effects of vitamin C and vitamin E on reserpine-induced oral dyskinesia in rats: Critical role of striatal catalase activity

Beneficial effects of vitamin C and vitamin E on reserpine-induced oral dyskinesia in rats: Critical role of striatal catalase activity

Autor Faria, R. R. Google Scholar
Abilio, V. C. Google Scholar
Grassl, C. Google Scholar
Chinen, C. C. Google Scholar
Takahashi, L. Google Scholar
Negrao, R. Google Scholar
Castroa, JPMV de Google Scholar
Fukushiro, D. F. Google Scholar
Rodrigues, MSD Google Scholar
Gomes, PHZ Google Scholar
Registro, S. Google Scholar
Carvalho, RDC de Google Scholar
D'Almeida, V Google Scholar
Silva, R. H. Google Scholar
Ribeiro, R. D. Google Scholar
Frussa-Filho, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Oral dyskinesias are implicated in a series of neuropathologies and have been associated to an increase in oxidative stress. Several antioxidants, including vitamin E, decrease reserpine-induced oral clyskinesia (OD) in rodents and we have described a protective role of striatal catalase against the development of OD. the aim of this study was to verify the effects of vitamin C alone or in combination with vitamin E on reserpine-induced OD as well as to determine a possible role of catalase in the antidyskinetic property of these vitamins. Different doses of vitamin C attenuated reserpine-induced increase in OD. A similar treatment with an effective dose of vitamin C concomitant to an effective dose of vitamin E potentiated the antidyskinetic effect of both vitamins when administered alone. the administration of these vitamins alone produced an increase in striatal catalase activity that likewise was potentiated by their combined administration. in addition, the antidyskinetic property of vitamin E and vitamin C was abolished by a concomitant treatment with the catalase inhibitor aminotriazole. These results indicate a beneficial effect of these vitamins and reinforce the critical role of striatal catalase against the development of oral dyskinesias. © 2005 Elsevier B.V. All rights reserved.
Palavra-chave oral dyskinesia
vitamin E
vitamin C
reserpine
catalase
oxidative stress
Idioma Inglês
Data de publicação 2005-06-01
Publicado em Neuropharmacology. Oxford: Pergamon-Elsevier B.V., v. 48, n. 7, p. 993-1001, 2005.
ISSN 0028-3908 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 993-1001
Fonte http://dx.doi.org/10.1016/j.neuropharm.2005.01.014
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000229160300008
Endereço permanente http://repositorio.unifesp.br/handle/11600/28327

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