Concentration of hyaluronic acid in primary open-angle glaucoma aqueous humor

Concentration of hyaluronic acid in primary open-angle glaucoma aqueous humor

Autor Navajas, E. V. Google Scholar
Martins, JRM Google Scholar
Melo, LAS Google Scholar
Saraiva, V. S. Google Scholar
Dietrich, C. P. Google Scholar
Nader, H. B. Google Scholar
Belfort, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo We compared the concentration of hyaluronic acid in the aqueous humor of primary open-angle glaucoma (POAG) patients and non-glaucomatous patients. Aqueous humor samples were obtained from 22 patients just before trabeculectomy for clinically uncontrolled POAG (POAG group). Aqueous humor (0.1 mL) was aspirated by inserting a 26-gauge needle into the anterior chamber. the same procedure was performed for 22 non-glaucomatous patients just before cataract surgery (control group). Immediately after collection, the aqueous humor was stored at -20 degrees C. the concentration of hyaluronic acid was determined by a sensitive, noncompetitive and nonisotopic fluoroassay. the median (range) concentrations of hyaluronic acid of the POAG and control groups were 298.4 mu g L-1 (99.0-743.7 mu g L-1) and 545.1 mu g L-1 (145.0-2366.0 mu g L-1), respectively. the difference in concentrations of hyaluronic acid between the groups was statistically significant (P < 0.001). in conclusion, the concentration of hyaluronic acid in the aqueous humor in POAG patients is lower than in non-glaucomatous patients. Further studies are necessary to determine the role of hyaluronic acid in the pathophysiology of POAG. (c) 2005 Elsevier B.V. All rights reserved.
Palavra-chave aqueous humor
hyaluronic acid
glaucoma
Idioma Inglês
Data de publicação 2005-06-01
Publicado em Experimental Eye Research. London: Academic Press Ltd Elsevier B.V., v. 80, n. 6, p. 853-857, 2005.
ISSN 0014-4835 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 853-857
Fonte http://dx.doi.org/10.1016/j.exer.2004.12.016
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000230161700013
Endereço permanente http://repositorio.unifesp.br/handle/11600/28324

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