Dentate gyrus-selective colchicine lesion and performance in temporal and spatial tasks

Dentate gyrus-selective colchicine lesion and performance in temporal and spatial tasks

Author Costa, VCI Google Scholar
Bueno, JLO Google Scholar
Xavier, G. F. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract The effects of multiple-site, intradentate, colchicine injections on the performance of a temporal. 'differential reinforcement of low rates of responding' (DRL-20 s) task and a spatial, 'delayed non-matching-to-place' (DNMTP) task in a plus-maze were investigated in rats trained in both tasks prior to the lesion. Quantitative analysis revealed a greater than 86% reduction in the dentate gyrus (DG) of the colchicine-injected rats compared to the sham-operated controls. Dentate gyrus damage rendered rats less efficient than sham-operated controls in the performance of the DRL-20 s task. the DRL inter-response time (IRT) distribution for the DG-lesioned rats and the sham-operated controls was similar; however, while the distribution peak for the control rats was 20 s, it was 16 s for the DG-lesioned rats, indicating that the latter rats underestimated time. Performance of the DG-lesioned rats was also disrupted in the DNMTP task. However, DG-lesioned rats recovered control levels of performance during repeated training with an intertrial interval equal to 3 s. An increase in intertrial interval in lesioned and sham-operated controls disrupted performance in both groups; however, while DG-lesioned rats performed at chance levels when the intertrial interval was increased to 4 min or longer, the sham-operated controls performed at chance levels only when the intertrial interval was increased to 16 min. These results seem most parsimoniously interpreted following the cognitive map theory of hippocampal function. (c) 2004 Elsevier B.V. All rights reserved.
Keywords hippocampus
dentate gyrus
cognitive map theory
working memory
timing process
spatial discrimination
NMTP task
DRL task
Language English
Date 2005-05-28
Published in Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 160, n. 2, p. 286-303, 2005.
ISSN 0166-4328 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 286-303
Access rights Closed access
Type Article
Web of Science ID WOS:000229276000009

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